| Position | Starters | Team | Opponents |
| C | Carson Kelly | ChN | SF(3) @NYN(3) |
| 1B | Matt Olson | Atl | Cin(4) @Pit(3) |
| 2B | Luke Keaschall | Min | Bal(3) SF(3) |
| SS | Bo Bichette | Tor | @LAA(3) @Sea(3) |
| 3B | Austin Riley | Atl | Cin(4) @Pit(3) |
| OF | Wilyer Abreu | Bos | Tex(3) @KC(3) |
| OF | Lawrence Butler | Oak | Sea(3) NYA(3) |
| OF | Oneil Cruz | Pit | @StL(3) Atl(3) |
| DH | Noelvi Marte | Cin | @Atl(4) @Hou(3) |
| Position | 1st Backup | Team | Opponents |
| C | Tyler Stephenson | Cin | @Atl(4) @Hou(3) |
| 1B (OF) | Eric Wagaman | Mia | LAD(3) @ChA(3) |
| 2B (3B,OF) | Jonathan India | KC | ChA(4) Bos(3) |
| SS | Jacob Wilson | Oak | Sea(3) NYA(3) |
| OF | Heliot Ramos | SF | @ChN(3) @Min(3) |
| DH | Andrew Benintendi | ChA | @KC(4) Mia(3) |
| Position | 2nd Backup | Team | Opponents |
| C | Edgar Quero | ChA | @KC(4) Mia(3) |
| OF | Justyn-Henry Malloy | Det | @Col(3) Tex(3) |
| DH | Chandler Simpson | TB | Phi(3) Mil(3) |
| Position | Bench | Team | Opponents |
| 1B | Jac Caglianone | KC | ChA(4) Bos(3) |
| 1B | Christian Encarnacion-Strand | Cin | @Atl(4) @Hou(3) |
| 3B | Matt Shaw | ChN | SF(3) @NYN(3) |
| OF | Roman Anthony | Bos | Tex(3) @KC(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Garrett Crochet | Bos | Tex(3) @KC(3) | Last Pitched Sunday May 4th |
| 2nd SP | Kodai Senga | NYN | @Ari(3) ChN(3) | This Wednesday at Ari (Merrill Kelly) |
| 3rd SP | Max Meyer | Mia | LAD(3) @ChA(3) | This Friday at ChA (Bryse Wilson) |
| 4th SP | Tyler Anderson | LAA | Tor(3) Bal(3) | This Tuesday vs Tor (TBD) |
| 5th SP | Tomoyuki Sugano | Bal | @Min(3) @LAA(3) | This Thursday at Min (Joe Ryan) |
| 6th SP | Justin Verlander | SF | @ChN(3) @Min(3) | This Tuesday at ChN (Colin Rea) |
| 7th SP | Pat Corbin | Tex | @Bos(3) @Det(3) | This Friday at Det (Jack Flaherty) |
| 8th SP (RP) | Colin Rea | ChN | SF(3) @NYN(3) | This Tuesday vs SF (Justin Verlander) |
| 1st RP | Edwin Diaz | NYN | @Ari(3) ChN(3) | Last Pitched Saturday April 26th |
| Position | Injured List | Team | Opponents |
| SP | Walker Buehler | Bos | Tex(3) @KC(3) |
| SP | Spencer Arrighetti | Hou | @Mil(3) Cin(3) |
| 2B | Zack Gelof | Oak | Sea(3) NYA(3) |