| Position | Starters | Team | Opponents |
| C | Will Smith | LAD | @Mia(3) @Ari(4) |
| 1B | Spencer Torkelson | Det | @Col(3) Tex(3) |
| 2B | Bryson Stott | Phi | @TB(3) @Cle(3) |
| SS | Mookie Betts | LAD | @Mia(3) @Ari(4) |
| 3B | Connor Norby | Mia | LAD(3) @ChA(3) |
| OF | Cody Bellinger | NYA | SD(3) @Oak(3) |
| OF | Steven Kwan | Cle | @Was(3) Phi(3) |
| OF | Andy Pages | LAD | @Mia(3) @Ari(4) |
| DH | Trea Turner | Phi | @TB(3) @Cle(3) |
| Position | 1st Backup | Team | Opponents |
| C | Agustin Ramirez | Mia | LAD(3) @ChA(3) |
| 1B | Christian Walker | Hou | @Mil(3) Cin(3) |
| 2B (OF) | Jose Altuve | Hou | @Mil(3) Cin(3) |
| SS | Geraldo Perdomo | Ari | NYN(3) LAD(4) |
| 3B | Ke'Bryan Hayes | Pit | @StL(3) Atl(3) |
| OF | Alek Thomas | Ari | NYN(3) LAD(4) |
| DH | Mike Trout | LAA | Tor(3) Bal(3) |
| Position | 2nd Backup | Team | Opponents |
| C | Ryan Jeffers | Min | Bal(3) SF(3) |
| DH (3B,OF,SS) | Jose Caballero | TB | Phi(3) Mil(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Jose Berrios | Tor | @LAA(3) @Sea(3) | This Wednesday at LAA (Yusei Kikuchi) |
| 2nd SP | Kris Bubic | KC | ChA(4) Bos(3) | This Thursday vs ChA (Davis Martin) |
| 3rd SP | Tony Gonsolin | LAD | @Mia(3) @Ari(4) | This Tuesday at Mia (Cal Quantrill) |
| 4th SP | Seth Lugo | KC | ChA(4) Bos(3) | This Tuesday vs ChA (Sean Burke) |
| 5th SP | Zac Gallen | Ari | NYN(3) LAD(4) | This Tuesday vs NYN (David Peterson) |
| 6th SP | Andrew Heaney | Pit | @StL(3) Atl(3) | This Saturday vs Atl (AJ Smith-Shawver) |
| 7th SP | Tyler Glasnow | LAD | @Mia(3) @Ari(4) | Last Pitched Sunday April 27th |
| 8th SP | David Peterson | NYN | @Ari(3) ChN(3) | This Tuesday at Ari (Zac Gallen) |
| 9th SP | Jameson Taillon | ChN | SF(3) @NYN(3) | This Friday at NYN (Clay Holmes) |
| 10th SP | Davis Martin | ChA | @KC(4) Mia(3) | This Thursday at KC (Kris Bubic) |
| 1st RP | José Alvarado | Phi | @TB(3) @Cle(3) | Last Pitched Friday May 2nd |
| 2nd RP | Tanner Scott | LAD | @Mia(3) @Ari(4) | Last Pitched Friday May 2nd |
| 3rd RP | Robert Suarez | SD | @NYA(3) @Col(3) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Opponents |
| OF | Parker Meadows | Det | @Col(3) Tex(3) |
| OF | Tyler O'Neill | Bal | @Min(3) @LAA(3) |
| 2B | Jake Cronenworth | SD | @NYA(3) @Col(3) |