| Position | Starters | Team | Opponents |
| C | Adley Rutschman | Bal | @Min(3) @LAA(3) |
| 1B | Paul Goldschmidt | NYA | SD(3) @Oak(3) |
| 2B | Gleyber Torres | Det | @Col(3) Tex(3) |
| SS | Gunnar Henderson | Bal | @Min(3) @LAA(3) |
| 3B | Max Muncy | LAD | @Mia(3) @Ari(4) |
| OF | Jackson Chourio | Mil | Hou(3) @TB(3) |
| OF | George Springer | Tor | @LAA(3) @Sea(3) |
| OF | Seiya Suzuki | ChN | SF(3) @NYN(3) |
| DH | Lars Nootbaar | StL | Pit(3) @Was(3) |
| Position | 1st Backup | Team | Opponents |
| C | Pedro Pages | StL | Pit(3) @Was(3) |
| 1B | Yandy Diaz | TB | Phi(3) Mil(3) |
| 2B (OF) | Tim Tawa | Ari | NYN(3) LAD(4) |
| SS | Masyn Winn | StL | Pit(3) @Was(3) |
| 3B (OF,SS) | Javier Baez | Det | @Col(3) Tex(3) |
| OF | TJ Friedl | Cin | @Atl(4) @Hou(3) |
| DH | Michael Harris II | Atl | Cin(4) @Pit(3) |
| Position | 2nd Backup | Team | Opponents |
| 2B (SS) | Jackson Holliday | Bal | @Min(3) @LAA(3) |
| OF | Brandon Nimmo | NYN | @Ari(3) ChN(3) |
| Position | Bench | Team | Opponents |
| SS (2B) | Kyle Farmer | Col | Det(3) SD(3) |
| SS | JJ Wetherholt | StL | Pit(3) @Was(3) |
| Pitching Staff Alignment |
| 10 Starts, 0 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Hunter Brown | Hou | @Mil(3) Cin(3) | Last Pitched Saturday May 3rd |
| 2nd SP | Logan Gilbert | Sea | @Oak(3) Tor(3) | Last Pitched Friday April 25th |
| 3rd SP | Dustin May | LAD | @Mia(3) @Ari(4) | This Saturday at Ari (Corbin Burnes) |
| 4th SP | Sonny Gray | StL | Pit(3) @Was(3) | This Wednesday vs Pit (Mitch Keller) |
| 5th SP | Corbin Burnes | Ari | NYN(3) LAD(4) | This Saturday vs LAD (Dustin May) |
| 6th SP | Bailey Ober | Min | Bal(3) SF(3) | This Friday vs SF (Jordan Hicks) |
| 7th SP | Tanner Bibee | Cle | @Was(3) Phi(3) | This Saturday vs Phi (Ranger Suarez) |
| 8th SP | Brayan Bello | Bos | Tex(3) @KC(3) | This Friday at KC (Mike Lorenzen) |
| 9th SP | Andre Pallante | StL | Pit(3) @Was(3) | This Saturday at Was (MacKenzie Gore) |
| 10th SP | Clarke Schmidt | NYA | SD(3) @Oak(3) | This Tuesday vs SD (Michael King) |
| 11th SP | Trevor Williams | Was | Cle(3) StL(3) | This Friday vs StL (Erick Fedde) |
| Position | Injured List | Team | Opponents |
| SS | Ha-seong Kim | TB | Phi(3) Mil(3) |
| SP | Yu Darvish | SD | @NYA(3) @Col(3) |
| SP | Zach Eflin | Bal | @Min(3) @LAA(3) |