| Position | Starters | Team | Opponents |
| C | Jonah Heim | Tex | @Bos(3) @Det(3) |
| 1B | Michael Toglia | Col | Det(3) SD(3) |
| 2B | Matt McLain | Cin | @Atl(4) @Hou(3) |
| SS | Jeremy Pena | Hou | @Mil(3) Cin(3) |
| 3B | Josh Jung | Tex | @Bos(3) @Det(3) |
| OF | Corbin Carroll | Ari | NYN(3) LAD(4) |
| OF | Jung Hoo Lee | SF | @ChN(3) @Min(3) |
| OF | Jackson Merrill | SD | @NYA(3) @Col(3) |
| DH (OF,1B) | Tyler Soderstrom | Oak | Sea(3) NYA(3) |
| Position | 1st Backup | Team | Opponents |
| C | Alejandro Kirk | Tor | @LAA(3) @Sea(3) |
| 1B (OF) | Spencer Steer | Cin | @Atl(4) @Hou(3) |
| 2B (OF,SS) | Kyren Paris | LAA | Tor(3) Bal(3) |
| SS | Anthony Volpe | NYA | SD(3) @Oak(3) |
| 3B (2B) | Jordan Westburg | Bal | @Min(3) @LAA(3) |
| OF | Riley Greene | Det | @Col(3) Tex(3) |
| DH | Andrew McCutchen | Pit | @StL(3) Atl(3) |
| Position | 2nd Backup | Team | Opponents |
| 1B | Triston Casas | Bos | Tex(3) @KC(3) |
| 2B | Brendan Rodgers | Hou | @Mil(3) Cin(3) |
| DH | Jordan Walker | StL | Pit(3) @Was(3) |
| Pitching Staff Alignment |
| 5 Starts, 3 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Spencer Schwellenbach | Atl | Cin(4) @Pit(3) | This Thursday vs Cin (Nick Lodolo) |
| 2nd SP | Bryan Woo | Sea | @Oak(3) Tor(3) | This Wednesday at Oak (Gunnar Hoglund) |
| 3rd SP | Tylor Megill | NYN | @Ari(3) ChN(3) | This Saturday vs ChN (Shota Imanaga) |
| 4th SP | Robbie Ray | SF | @ChN(3) @Min(3) | This Wednesday at ChN (Ben Brown) |
| 5th SP | Landen Roupp | SF | @ChN(3) @Min(3) | This Monday at ChN (Matt Boyd) |
| 6th SP | Jack Leiter | Tex | @Bos(3) @Det(3) | This Thursday at Bos (Tanner Houck) |
| 7th SP | Max Scherzer | Tor | @LAA(3) @Sea(3) | Last Pitched Saturday March 29th |
| 8th SP | Chase Burns | Cin | @Atl(4) @Hou(3) | Has Not Played Yet |
| 1st RP | Mason Miller | Oak | Sea(3) NYA(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Carlos Estevez | KC | ChA(4) Bos(3) | Last Pitched Wednesday April 30th |
| 3rd RP | David Bednar | Pit | @StL(3) Atl(3) | Last Pitched Saturday May 3rd |
| 4th RP | Cade Smith | Cle | @Was(3) Phi(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Opponents |
| SP | Richard Fitts | Bos | Tex(3) @KC(3) |
| SP | George Kirby | Sea | @Oak(3) Tor(3) |
| SP | Grayson Rodriguez | Bal | @Min(3) @LAA(3) |