| Position | Starters | Team | Opponents |
| C | Dillon Dingler | Det | @Col(3) Tex(3) |
| 1B | Vladimir Guerrero Jr. | Tor | @LAA(3) @Sea(3) |
| 2B | Wilmer Flores | SF | @ChN(3) @Min(3) |
| SS | Willy Adames | SF | @ChN(3) @Min(3) |
| 3B | Rafael Devers | Bos | Tex(3) @KC(3) |
| OF | Yordan Alvarez | Hou | @Mil(3) Cin(3) |
| OF | Jordan Beck | Col | Det(3) SD(3) |
| OF | Juan Soto | NYN | @Ari(3) ChN(3) |
| DH (OF,1B) | Ryan O'Hearn | Bal | @Min(3) @LAA(3) |
| Position | 1st Backup | Team | Opponents |
| C | Gabriel Moreno | Ari | NYN(3) LAD(4) |
| 1B | Nolan Schanuel | LAA | Tor(3) Bal(3) |
| 2B | Nico Hoerner | ChN | SF(3) @NYN(3) |
| SS | J.P. Crawford | Sea | @Oak(3) Tor(3) |
| OF | Christopher Morel | TB | Phi(3) Mil(3) |
| DH | Brandon Lowe | TB | Phi(3) Mil(3) |
| Position | Bench | Team | Opponents |
| C | Dalton Rushing | LAD | @Mia(3) @Ari(4) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Hunter Greene | Cin | @Atl(4) @Hou(3) | This Wednesday at Atl (Grant Holmes) |
| 2nd SP | Max Fried | NYA | SD(3) @Oak(3) | This Friday at Oak (Osvaldo Bido) |
| 3rd SP | Framber Valdez | Hou | @Mil(3) Cin(3) | This Friday vs Cin (Nick Martinez) |
| 4th SP | Logan Webb | SF | @ChN(3) @Min(3) | This Saturday at Min (Chris Paddack) |
| 5th SP | Jose Quintana | Mil | Hou(3) @TB(3) | This Friday at TB (Zack Littell) |
| 6th SP | Matt Boyd | ChN | SF(3) @NYN(3) | This Monday vs SF (Landen Roupp) |
| 7th SP | Hunter Dobbins | Bos | Tex(3) @KC(3) | This Saturday at KC (Cole Ragans) |
| 8th SP | JP Sears | Oak | Sea(3) NYA(3) | This Saturday vs NYA (Will Warren) |
| 9th SP | Ronel Blanco | Hou | @Mil(3) Cin(3) | This Monday at Mil (Tobias Myers) |
| 10th SP | Spencer Strider | Atl | Cin(4) @Pit(3) | Last Pitched Wednesday April 16th |
| 11th SP | Bubba Chandler | Pit | @StL(3) Atl(3) | Has Not Played Yet |
| 12th SP | Jacob Misiorowski | Mil | Hou(3) @TB(3) | Has Not Played Yet |
| 1st RP | Kyle Finnegan | Was | Cle(3) StL(3) | Last Pitched Thursday May 1st |
| 2nd RP | Raisel Iglesias | Atl | Cin(4) @Pit(3) | Last Pitched Saturday May 3rd |
| 3rd RP | Jhoan Duran | Min | Bal(3) SF(3) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Opponents |
| C | Ivan Herrera | StL | Pit(3) @Was(3) |
| 3B (2B,OF) | Dylan Moore | Sea | @Oak(3) Tor(3) |
| OF | Ronald Acuna Jr. | Atl | Cin(4) @Pit(3) |