| Position | Starters | Team | Opponents |
| C | William Contreras | Mil | Hou(3) @TB(3) |
| 1B | Bryce Harper | Phi | @TB(3) @Cle(3) |
| 2B | Ketel Marte | Ari | NYN(3) LAD(4) |
| SS | Bobby Witt Jr. | KC | ChA(4) Bos(3) |
| 3B | Alex Bregman | Bos | Tex(3) @KC(3) |
| OF | Randy Arozarena | Sea | @Oak(3) Tor(3) |
| OF | Brent Rooker | Oak | Sea(3) NYA(3) |
| OF | Kyle Tucker | ChN | SF(3) @NYN(3) |
| DH | Jarren Duran | Bos | Tex(3) @KC(3) |
| Position | 1st Backup | Team | Opponents |
| C | Logan O'Hoppe | LAA | Tor(3) Bal(3) |
| 1B | Ryan Mountcastle | Bal | @Min(3) @LAA(3) |
| 2B (SS,OF) | Brendan Donovan | StL | Pit(3) @Was(3) |
| SS | Xander Bogaerts | SD | @NYA(3) @Col(3) |
| 3B | Nolan Arenado | StL | Pit(3) @Was(3) |
| OF | Lourdes Gurriel | Ari | NYN(3) LAD(4) |
| DH | Trent Grisham | NYA | SD(3) @Oak(3) |
| Position | 2nd Backup | Team | Opponents |
| 2B | Andrés Gimenez | Tor | @LAA(3) @Sea(3) |
| OF | JJ Bleday | Oak | Sea(3) NYA(3) |
| DH (2B,OF,3B) | Maikel Garcia | KC | ChA(4) Bos(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Cole Ragans | KC | ChA(4) Bos(3) |
This Monday vs ChA (Shane Smith)
This Saturday vs Bos (Hunter Dobbins) |
| 2nd SP | Joe Ryan | Min | Bal(3) SF(3) | This Thursday vs Bal (Tomoyuki Sugano) |
| 3rd SP | Carlos Rodon | NYA | SD(3) @Oak(3) | This Monday vs SD (Nick Pivetta) |
| 4th SP | Brandon Pfaadt | Ari | NYN(3) LAD(4) | This Thursday vs LAD (Yoshinobu Yamamoto) |
| 5th SP | Dylan Cease | SD | @NYA(3) @Col(3) | This Wednesday at NYA (Carlos Carrasco) |
| 6th SP | Brandon Woodruff | Mil | Hou(3) @TB(3) | Has Not Played Yet |
| 7th SP | Taj Bradley | TB | Phi(3) Mil(3) | This Saturday vs Mil (Freddy Peralta) |
| 8th SP | Matthew Liberatore | StL | Pit(3) @Was(3) | This Tuesday vs Pit (Paul Skenes) |
| 9th SP | Michael Wacha | KC | ChA(4) Bos(3) | This Wednesday vs ChA (Jonathan Cannon) |
| 10th SP | Jake Irvin | Was | Cle(3) StL(3) | This Monday vs Cle (Luis Ortiz) |
| 1st RP | Andres Munoz | Sea | @Oak(3) Tor(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Jeff Hoffman | Tor | @LAA(3) @Sea(3) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Opponents |
| SP | Luis Gil | NYA | SD(3) @Oak(3) |