| Position | Starters | Team | Opponents |
| C (OF) | Hunter Goodman | Col | Det(3) SD(3) |
| 1B | Kyle Manzardo | Cle | @Was(3) Phi(3) |
| 2B | Brice Turang | Mil | Hou(3) @TB(3) |
| SS | Carlos Correa | Min | Bal(3) SF(3) |
| 3B | Mark Vientos | NYN | @Ari(3) ChN(3) |
| OF (2B) | Kristian Campbell | Bos | Tex(3) @KC(3) |
| OF | Ian Happ | ChN | SF(3) @NYN(3) |
| OF | Christian Yelich | Mil | Hou(3) @TB(3) |
| DH | Kyle Schwarber | Phi | @TB(3) @Cle(3) |
| Position | 1st Backup | Team | Opponents |
| C | Keibert Ruiz | Was | Cle(3) StL(3) |
| 1B | Vinnie Pasquantino | KC | ChA(4) Bos(3) |
| SS (3B) | Joey Ortiz | Mil | Hou(3) @TB(3) |
| OF | Kyle Stowers | Mia | LAD(3) @ChA(3) |
| DH | Victor Scott | StL | Pit(3) @Was(3) |
| Position | Bench | Team | Opponents |
| 1B | Deyvison De Los Santos | Mia | LAD(3) @ChA(3) |
| 1B | Matt Mervis | Mia | LAD(3) @ChA(3) |
| 3B | Brady House | Was | Cle(3) StL(3) |
| 3B | Coby Mayo | Bal | @Min(3) @LAA(3) |
| OF | Evan Carter | Tex | @Bos(3) @Det(3) |
| OF | Austin Hays | Cin | @Atl(4) @Hou(3) |
| OF | Colby Thomas | Oak | Sea(3) NYA(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Kevin Gausman | Tor | @LAA(3) @Sea(3) | This Friday at Sea (Luis Castillo) |
| 2nd SP | Bryce Miller | Sea | @Oak(3) Tor(3) | This Monday at Oak (Luis Severino) |
| 3rd SP | Yoshinobu Yamamoto | LAD | @Mia(3) @Ari(4) | This Thursday at Ari (Brandon Pfaadt) |
| 4th SP | Andrew Abbott | Cin | @Atl(4) @Hou(3) |
This Tuesday at Atl (Chris Sale)
This Saturday at Hou (Lance McCullers) |
| 5th SP | Luis Ortiz | Cle | @Was(3) Phi(3) | This Monday at Was (Jake Irvin) |
| 6th SP | José Soriano | LAA | Tor(3) Bal(3) | This Thursday vs Tor (Chris Bassitt) |
| 7th SP | Grant Holmes | Atl | Cin(4) @Pit(3) | This Wednesday vs Cin (Hunter Greene) |
| 8th SP | Andrew Painter | Phi | @TB(3) @Cle(3) | Has Not Played Yet |
| 9th SP | Zebby Matthews | Min | Bal(3) SF(3) | Has Not Played Yet |
| 1st RP | Kenley Jansen | LAA | Tor(3) Bal(3) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Opponents |
| SS (3B) | Paul DeJong | Was | Cle(3) StL(3) |
| OF | Jerar Encarnación | SF | @ChN(3) @Min(3) |
| SP | Ryan Weathers | Mia | LAD(3) @ChA(3) |