| Position | Starters | Team | Opponents |
| C | Will Smith | LAD | @Mia(3) @Ari(4) |
| 1B | Vladimir Guerrero Jr. | Tor | @LAA(3) @Sea(3) |
| 2B | Ketel Marte | Ari | NYN(3) LAD(4) |
| SS | Jacob Wilson | Oak | Sea(3) NYA(3) |
| 3B | Alex Bregman | Bos | Tex(3) @KC(3) |
| OF | Bryan Reynolds | Pit | @StL(3) Atl(3) |
| OF | Brent Rooker | Oak | Sea(3) NYA(3) |
| OF | George Springer | Tor | @LAA(3) @Sea(3) |
| DH | Marcell Ozuna | Atl | Cin(4) @Pit(3) |
| Position | 1st Backup | Team | Opponents |
| C (1B,C) | Salvador Perez | KC | ChA(4) Bos(3) |
| 1B | Nathaniel Lowe | Was | Cle(3) StL(3) |
| 2B | Nick Gonzales | Pit | @StL(3) Atl(3) |
| SS | Ezequiel Tovar | Col | Det(3) SD(3) |
| 3B (OF,SS) | Jose Caballero | TB | Phi(3) Mil(3) |
| OF | Adolis Garcia | Tex | @Bos(3) @Det(3) |
| DH (1B,OF) | Spencer Steer | Cin | @Atl(4) @Hou(3) |
| Position | 2nd Backup | Team | Opponents |
| 2B (1B) | Romy Gonzalez | Bos | Tex(3) @KC(3) |
| OF | Jordan Walker | StL | Pit(3) @Was(3) |
| Position | 3rd Backup | Team | Opponents |
| 2B | Brendan Rodgers | Hou | @Mil(3) Cin(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | George Kirby | Sea | @Oak(3) Tor(3) | Has Not Played Yet |
| 2nd SP | Carlos Rodon | NYA | SD(3) @Oak(3) | This Monday vs SD (Nick Pivetta) |
| 3rd SP | Framber Valdez | Hou | @Mil(3) Cin(3) | This Friday vs Cin (Nick Martinez) |
| 4th SP | Shane Baz | TB | Phi(3) Mil(3) | This Wednesday vs Phi (Cristopher Sanchez) |
| 5th SP | Tomoyuki Sugano | Bal | @Min(3) @LAA(3) | This Thursday at Min (Joe Ryan) |
| 6th SP | Merrill Kelly | Ari | NYN(3) LAD(4) | This Wednesday vs NYN (Kodai Senga) |
| 7th SP | Bowden Francis | Tor | @LAA(3) @Sea(3) | This Saturday at Sea (Logan Evans) |
| 8th SP | Erick Fedde | StL | Pit(3) @Was(3) | This Friday at Was (Trevor Williams) |
| 9th SP | Randy Vasquez | SD | @NYA(3) @Col(3) | This Friday at Col (Bradley Blalock) |
| 1st RP | Kyle Finnegan | Was | Cle(3) StL(3) | Last Pitched Thursday May 1st |
| 2nd RP | Ryan Pressly | ChN | SF(3) @NYN(3) | Last Pitched Thursday May 1st |
| 3rd RP | Trevor Megill | Mil | Hou(3) @TB(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Opponents |
| 3B | Matt Vierling | Det | @Col(3) Tex(3) |
| SP | Yu Darvish | SD | @NYA(3) @Col(3) |
| SP | Reynaldo Lopez | Atl | Cin(4) @Pit(3) |