| Position | Starters | Team | Opponents |
| C | Agustin Ramirez | Mia | LAD(3) @ChA(3) |
| 1B | Bryce Harper | Phi | @TB(3) @Cle(3) |
| 2B (3B,SS) | Gabriel Arias | Cle | @Was(3) Phi(3) |
| SS | Corey Seager | Tex | @Bos(3) @Det(3) |
| 3B | Jorge Polanco | Sea | @Oak(3) Tor(3) |
| OF | Lawrence Butler | Oak | Sea(3) NYA(3) |
| OF | Oneil Cruz | Pit | @StL(3) Atl(3) |
| OF | James Wood | Was | Cle(3) StL(3) |
| DH | Shohei Ohtani | LAD | @Mia(3) @Ari(4) |
| Position | 1st Backup | Team | Opponents |
| C | Dillon Dingler | Det | @Col(3) Tex(3) |
| 1B | Nick Kurtz | Oak | Sea(3) NYA(3) |
| 2B | Christian Moore | LAA | Tor(3) Bal(3) |
| SS | Jordan Lawlar | Ari | NYN(3) LAD(4) |
| 3B | Coby Mayo | Bal | @Min(3) @LAA(3) |
| OF | Kerry Carpenter | Det | @Col(3) Tex(3) |
| DH | Ben Rice | NYA | SD(3) @Oak(3) |
| Position | 2nd Backup | Team | Opponents |
| 1B | Jac Caglianone | KC | ChA(4) Bos(3) |
| 2B | Otto Lopez | Mia | LAD(3) @ChA(3) |
| SS | Bo Bichette | Tor | @LAA(3) @Sea(3) |
| 3B | Ryan McMahon | Col | Det(3) SD(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Tarik Skubal | Det | @Col(3) Tex(3) | This Thursday at Col (Antonio Senzatela) |
| 2nd SP | Kris Bubic | KC | ChA(4) Bos(3) | This Thursday vs ChA (Davis Martin) |
| 3rd SP | Drew Rasmussen | TB | Phi(3) Mil(3) | This Tuesday vs Phi (Zack Wheeler) |
| 4th SP | Nick Lodolo | Cin | @Atl(4) @Hou(3) | This Thursday at Atl (Spencer Schwellenbach) |
| 5th SP | Tanner Bibee | Cle | @Was(3) Phi(3) | This Saturday vs Phi (Ranger Suarez) |
| 6th SP | Reese Olson | Det | @Col(3) Tex(3) | This Saturday vs Tex (Jacob deGrom) |
| 7th SP | Zebby Matthews | Min | Bal(3) SF(3) | Has Not Played Yet |
| 8th SP | Tony Gonsolin | LAD | @Mia(3) @Ari(4) | This Tuesday at Mia (Cal Quantrill) |
| 1st RP | Jeff Hoffman | Tor | @LAA(3) @Sea(3) | Last Pitched Friday May 2nd |
| 2nd RP | Emilio Pagan | Cin | @Atl(4) @Hou(3) | Last Pitched Friday May 2nd |
| 3rd RP | Ryan Walker | SF | @ChN(3) @Min(3) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Opponents |
| OF | Ronald Acuna Jr. | Atl | Cin(4) @Pit(3) |
| OF | Josh Lowe | TB | Phi(3) Mil(3) |
| SP | Ryan Weathers | Mia | LAD(3) @ChA(3) |