| Position | Starters | Team | Opponents |
| C | Shea Langeliers | Oak | Sea(3) NYA(3) |
| 1B | Pete Alonso | NYN | @Ari(3) ChN(3) |
| 2B (OF) | Jose Altuve | Hou | @Mil(3) Cin(3) |
| SS | Francisco Lindor | NYN | @Ari(3) ChN(3) |
| 3B | Mark Vientos | NYN | @Ari(3) ChN(3) |
| OF | Corbin Carroll | Ari | NYN(3) LAD(4) |
| OF | Sal Frelick | Mil | Hou(3) @TB(3) |
| OF | Luis Robert Jr. | ChA | @KC(4) Mia(3) |
| DH | Michael Busch | ChN | SF(3) @NYN(3) |
| Position | 1st Backup | Team | Opponents |
| 1B | Ty France | Min | Bal(3) SF(3) |
| 2B | Nolan Gorman | StL | Pit(3) @Was(3) |
| SS | Xander Bogaerts | SD | @NYA(3) @Col(3) |
| 3B (OF,2B) | Zach McKinstry | Det | @Col(3) Tex(3) |
| OF | Dylan Crews | Was | Cle(3) StL(3) |
| DH | JJ Bleday | Oak | Sea(3) NYA(3) |
| Position | 2nd Backup | Team | Opponents |
| 2B (OF,3B) | Maikel Garcia | KC | ChA(4) Bos(3) |
| OF | Jesus Sanchez | Mia | LAD(3) @ChA(3) |
| Position | Bench | Team | Opponents |
| C | Jose Trevino | Cin | @Atl(4) @Hou(3) |
| OF | Roman Anthony | Bos | Tex(3) @KC(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Zack Wheeler | Phi | @TB(3) @Cle(3) | This Tuesday at TB (Drew Rasmussen) |
| 2nd SP | Kodai Senga | NYN | @Ari(3) ChN(3) | This Wednesday at Ari (Merrill Kelly) |
| 3rd SP | Roki Sasaki | LAD | @Mia(3) @Ari(4) | This Friday at Ari (Eduardo Rodriguez) |
| 4th SP | Tyler Mahle | Tex | @Bos(3) @Det(3) | This Wednesday at Bos (Lucas Giolito) |
| 5th SP | Dylan Cease | SD | @NYA(3) @Col(3) | This Wednesday at NYA (Carlos Carrasco) |
| 6th SP | Zack Littell | TB | Phi(3) Mil(3) | This Friday vs Mil (Jose Quintana) |
| 7th SP | Zach Eflin | Bal | @Min(3) @LAA(3) | Last Pitched Monday April 7th |
| 1st RP (SP) | Luke Weaver | NYA | SD(3) @Oak(3) | Last Pitched Friday May 2nd |
| 2nd RP | Pete Fairbanks | TB | Phi(3) Mil(3) | Last Pitched Saturday May 3rd |
| 3rd RP | Raisel Iglesias | Atl | Cin(4) @Pit(3) | Last Pitched Saturday May 3rd |
| 4th RP | Devin Williams | NYA | SD(3) @Oak(3) | Last Pitched Friday May 2nd |
| 5th RP | Tommy Kahnle | Det | @Col(3) Tex(3) | Last Pitched Thursday May 1st |
| Position | Injured List | Team | Opponents |
| SP | Max Scherzer | Tor | @LAA(3) @Sea(3) |
| SP | Shane Bieber | Cle | @Was(3) Phi(3) |
| SP | Brandon Woodruff | Mil | Hou(3) @TB(3) |