| Position | Starters | Team | Opponents |
| C | Adley Rutschman | Bal | @Min(3) @LAA(3) |
| 1B | Willson Contreras | StL | Pit(3) @Was(3) |
| 2B | Brandon Lowe | TB | Phi(3) Mil(3) |
| SS | Geraldo Perdomo | Ari | NYN(3) LAD(4) |
| 3B | Jose Ramirez | Cle | @Was(3) Phi(3) |
| OF | Michael Conforto | LAD | @Mia(3) @Ari(4) |
| OF | Lourdes Gurriel | Ari | NYN(3) LAD(4) |
| OF | Matt Wallner | Min | Bal(3) SF(3) |
| DH | Anthony Santander | Tor | @LAA(3) @Sea(3) |
| Position | 1st Backup | Team | Opponents |
| C | Carson Kelly | ChN | SF(3) @NYN(3) |
| 1B | Ryan Mountcastle | Bal | @Min(3) @LAA(3) |
| 2B (SS) | Jackson Holliday | Bal | @Min(3) @LAA(3) |
| SS (3B) | Joey Ortiz | Mil | Hou(3) @TB(3) |
| 3B | Junior Caminero | TB | Phi(3) Mil(3) |
| OF | Jo Adell | LAA | Tor(3) Bal(3) |
| DH | Carlos Santana | Cle | @Was(3) Phi(3) |
| Position | Bench | Team | Opponents |
| SS (2B) | Tyler Freeman | Col | Det(3) SD(3) |
| SS (3B) | Jose Tena | Was | Cle(3) StL(3) |
| 3B (2B) | Luis Urias | Oak | Sea(3) NYA(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Paul Skenes | Pit | @StL(3) Atl(3) | This Tuesday at StL (Matthew Liberatore) |
| 2nd SP | Jacob deGrom | Tex | @Bos(3) @Det(3) | This Saturday at Det (Reese Olson) |
| 3rd SP | Gavin Williams | Cle | @Was(3) Phi(3) | This Friday vs Phi (Aaron Nola) |
| 4th SP | Yoshinobu Yamamoto | LAD | @Mia(3) @Ari(4) | This Thursday at Ari (Brandon Pfaadt) |
| 5th SP | Jackson Jobe | Det | @Col(3) Tex(3) | This Tuesday at Col (Chase Dollander) |
| 6th SP | Nick Pivetta | SD | @NYA(3) @Col(3) | This Monday at NYA (Carlos Rodon) |
| 7th SP | Yusei Kikuchi | LAA | Tor(3) Bal(3) | This Wednesday vs Tor (Jose Berrios) |
| 8th SP | Cody Bradford | Tex | @Bos(3) @Det(3) | Has Not Played Yet |
| 9th SP | Bobby Miller | LAD | @Mia(3) @Ari(4) | Last Pitched Wednesday April 16th |
| 1st RP | Andres Munoz | Sea | @Oak(3) Tor(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Mason Miller | Oak | Sea(3) NYA(3) | Last Pitched Saturday May 3rd |
| 3rd RP | Porter Hodge | ChN | SF(3) @NYN(3) | Last Pitched Thursday May 1st |
| Position | Injured List | Team | Opponents |
| SP | Spencer Arrighetti | Hou | @Mil(3) Cin(3) |
| SP | Alexander Cobb | Det | @Col(3) Tex(3) |