| Position | Starters | Team | Opponents |
| C | Yainer Diaz | Hou | @Mil(3) Cin(3) |
| 1B | Matt Olson | Atl | Cin(4) @Pit(3) |
| 2B | Marcus Semien | Tex | @Bos(3) @Det(3) |
| SS | Dansby Swanson | ChN | SF(3) @NYN(3) |
| 3B (2B) | Jordan Westburg | Bal | @Min(3) @LAA(3) |
| OF | Michael Harris II | Atl | Cin(4) @Pit(3) |
| OF | Steven Kwan | Cle | @Was(3) Phi(3) |
| OF | Fernando Tatis Jr. | SD | @NYA(3) @Col(3) |
| DH (2B,OF,3B) | Dylan Moore | Sea | @Oak(3) Tor(3) |
| Position | 1st Backup | Team | Opponents |
| C | Gabriel Moreno | Ari | NYN(3) LAD(4) |
| SS | Jeremy Pena | Hou | @Mil(3) Cin(3) |
| OF | Jasson Dominguez | NYA | SD(3) @Oak(3) |
| DH | Xavier Edwards | Mia | LAD(3) @ChA(3) |
| Position | 2nd Backup | Team | Opponents |
| OF | Victor Scott | StL | Pit(3) @Was(3) |
| Position | 3rd Backup | Team | Opponents |
| OF | Daulton Varsho | Tor | @LAA(3) @Sea(3) |
| Position | Bench | Team | Opponents |
| 1B | Luis Arraez | SD | @NYA(3) @Col(3) |
| 2B (SS,3B) | Willi Castro | Min | Bal(3) SF(3) |
| SS | Masyn Winn | StL | Pit(3) @Was(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Garrett Crochet | Bos | Tex(3) @KC(3) | Last Pitched Sunday May 4th |
| 2nd SP | Shota Imanaga | ChN | SF(3) @NYN(3) | This Saturday at NYN (Tylor Megill) |
| 3rd SP | Hunter Greene | Cin | @Atl(4) @Hou(3) | This Wednesday at Atl (Grant Holmes) |
| 4th SP | Sonny Gray | StL | Pit(3) @Was(3) | This Wednesday vs Pit (Mitch Keller) |
| 5th SP | Joe Ryan | Min | Bal(3) SF(3) | This Thursday vs Bal (Tomoyuki Sugano) |
| 6th SP | Pablo Lopez | Min | Bal(3) SF(3) | This Tuesday vs Bal (Cade Povich) |
| 7th SP | Brandon Pfaadt | Ari | NYN(3) LAD(4) | This Thursday vs LAD (Yoshinobu Yamamoto) |
| 8th SP | Bailey Ober | Min | Bal(3) SF(3) | This Friday vs SF (Jordan Hicks) |
| 9th SP | Chris Bassitt | Tor | @LAA(3) @Sea(3) | This Thursday at LAA (José Soriano) |
| 10th SP | Ryan Pepiot | TB | Phi(3) Mil(3) | This Thursday vs Phi (Jesus Luzardo) |
| 11th SP | Shane Smith | ChA | @KC(4) Mia(3) |
This Monday at KC (Cole Ragans)
This Saturday vs Mia (Edward Cabrera) |
| 1st RP | Josh Hader | Hou | @Mil(3) Cin(3) | Last Pitched Tuesday April 29th |
| 2nd RP | Felix Bautista | Bal | @Min(3) @LAA(3) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Opponents |
| OF | Parker Meadows | Det | @Col(3) Tex(3) |
| SP | Gerrit Cole | NYA | SD(3) @Oak(3) |
| SP | Nestor Cortes Jr. | Mil | Hou(3) @TB(3) |