| Position | Starters | Team | Opponents |
| C | Cal Raleigh | Sea | @Oak(3) Tor(3) |
| 1B | Vinnie Pasquantino | KC | ChA(4) Bos(3) |
| 2B | Brice Turang | Mil | Hou(3) @TB(3) |
| SS | Willy Adames | SF | @ChN(3) @Min(3) |
| 3B | Rafael Devers | Bos | Tex(3) @KC(3) |
| OF | Nick Castellanos | Phi | @TB(3) @Cle(3) |
| OF | Aaron Judge | NYA | SD(3) @Oak(3) |
| OF | Seiya Suzuki | ChN | SF(3) @NYN(3) |
| DH | Mike Trout | LAA | Tor(3) Bal(3) |
| Position | 1st Backup | Team | Opponents |
| C | Jonah Heim | Tex | @Bos(3) @Det(3) |
| 1B | Nolan Schanuel | LAA | Tor(3) Bal(3) |
| 2B (OF) | Gavin Lux | Cin | @Atl(4) @Hou(3) |
| SS | Zach Neto | LAA | Tor(3) Bal(3) |
| 3B (SS) | Josh Smith | Tex | @Bos(3) @Det(3) |
| OF | Ceddanne Rafaela | Bos | Tex(3) @KC(3) |
| DH | Andrés Gimenez | Tor | @LAA(3) @Sea(3) |
| Position | Bench | Team | Opponents |
| C | Tyler Stephenson | Cin | @Atl(4) @Hou(3) |
| DH (2B,SS) | Max Muncy | Oak | Sea(3) NYA(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Cole Ragans | KC | ChA(4) Bos(3) |
This Monday vs ChA (Shane Smith)
This Saturday vs Bos (Hunter Dobbins) |
| 2nd SP | Aaron Nola | Phi | @TB(3) @Cle(3) | This Friday at Cle (Gavin Williams) |
| 3rd SP | Zac Gallen | Ari | NYN(3) LAD(4) | This Tuesday vs NYN (David Peterson) |
| 4th SP | Jameson Taillon | ChN | SF(3) @NYN(3) | This Friday at NYN (Clay Holmes) |
| 5th SP | Brayan Bello | Bos | Tex(3) @KC(3) | This Friday at KC (Mike Lorenzen) |
| 6th SP | Mitch Keller | Pit | @StL(3) Atl(3) | This Wednesday at StL (Sonny Gray) |
| 7th SP | Matt Boyd | ChN | SF(3) @NYN(3) | This Monday vs SF (Landen Roupp) |
| 8th SP | Bubba Chandler | Pit | @StL(3) Atl(3) | Has Not Played Yet |
| 9th SP | Ben Brown | ChN | SF(3) @NYN(3) | This Wednesday vs SF (Robbie Ray) |
| 10th SP | Justin Steele | ChN | SF(3) @NYN(3) | Last Pitched Monday April 7th |
| 1st RP | Emmanuel Clase | Cle | @Was(3) Phi(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Will Vest | Det | @Col(3) Tex(3) | Last Pitched Tuesday April 29th |
| 3rd RP | Shelby Miller | Ari | NYN(3) LAD(4) | Last Pitched Thursday May 1st |
| Position | Injured List | Team | Opponents |
| SP | Tyler Glasnow | LAD | @Mia(3) @Ari(4) |
| RP | Justin Martinez | Ari | NYN(3) LAD(4) |
| SS | Ha-seong Kim | TB | Phi(3) Mil(3) |