| Position | Starters | Team | Opponents |
| C | Drake Baldwin | Atl | Cin(4) @Pit(3) |
| 1B (OF) | Tyler Soderstrom | Oak | Sea(3) NYA(3) |
| 2B (OF) | Kristian Campbell | Bos | Tex(3) @KC(3) |
| SS | Carlos Correa | Min | Bal(3) SF(3) |
| 3B | Noelvi Marte | Cin | @Atl(4) @Hou(3) |
| OF | Pete Crow-Armstrong | ChN | SF(3) @NYN(3) |
| OF | Jung Hoo Lee | SF | @ChN(3) @Min(3) |
| OF | Lars Nootbaar | StL | Pit(3) @Was(3) |
| DH | Kyle Manzardo | Cle | @Was(3) Phi(3) |
| Position | 1st Backup | Team | Opponents |
| C | Alejandro Kirk | Tor | @LAA(3) @Sea(3) |
| 1B | Jake Burger | Tex | @Bos(3) @Det(3) |
| 2B | Gleyber Torres | Det | @Col(3) Tex(3) |
| SS | J.P. Crawford | Sea | @Oak(3) Tor(3) |
| 3B | Max Muncy | LAD | @Mia(3) @Ari(4) |
| OF | Mike Yastrzemski | SF | @ChN(3) @Min(3) |
| Position | 2nd Backup | Team | Opponents |
| OF | Chandler Simpson | TB | Phi(3) Mil(3) |
| DH (2B,SS) | Adael Amador | Col | Det(3) SD(3) |
| Position | Bench | Team | Opponents |
| C | Dalton Rushing | LAD | @Mia(3) @Ari(4) |
| 1B | Deyvison De Los Santos | Mia | LAD(3) @ChA(3) |
| OF | Colton Cowser | Bal | @Min(3) @LAA(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Sandy Alcantara | Mia | LAD(3) @ChA(3) | This Monday vs LAD (TBD) |
| 2nd SP | Spencer Schwellenbach | Atl | Cin(4) @Pit(3) | This Thursday vs Cin (Nick Lodolo) |
| 3rd SP | Tylor Megill | NYN | @Ari(3) ChN(3) | This Saturday vs ChN (Shota Imanaga) |
| 4th SP | Jeffrey Springs | Oak | Sea(3) NYA(3) | This Tuesday vs Sea (Emerson Hancock) |
| 5th SP | Andrew Abbott | Cin | @Atl(4) @Hou(3) |
This Tuesday at Atl (Chris Sale)
This Saturday at Hou (Lance McCullers) |
| 6th SP | Landen Roupp | SF | @ChN(3) @Min(3) | This Monday at ChN (Matt Boyd) |
| 7th SP | Griffin Canning | NYN | @Ari(3) ChN(3) | This Monday at Ari (TBD) |
| 8th SP | Osvaldo Bido | Oak | Sea(3) NYA(3) | This Friday vs NYA (Max Fried) |
| 9th SP | Andrew Painter | Phi | @TB(3) @Cle(3) | Has Not Played Yet |
| 1st RP | Ryan Helsley | StL | Pit(3) @Was(3) | Last Pitched Friday May 2nd |
| 2nd RP | Alexis Diaz | Cin | @Atl(4) @Hou(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Opponents |
| C | Ivan Herrera | StL | Pit(3) @Was(3) |
| 2B | Zack Gelof | Oak | Sea(3) NYA(3) |
| 3B | Royce Lewis | Min | Bal(3) SF(3) |