| Position | Starters | Team | Opponents |
| C | Tyler Stephenson | Cin | @Atl(4) @Hou(3) |
| 1B | Bryce Harper | Phi | @TB(3) @Cle(3) |
| 2B | Gleyber Torres | Det | @Col(3) Tex(3) |
| SS | CJ Abrams | Was | Cle(3) StL(3) |
| 3B | Austin Riley | Atl | Cin(4) @Pit(3) |
| OF | Oneil Cruz | Pit | @StL(3) Atl(3) |
| OF | Riley Greene | Det | @Col(3) Tex(3) |
| OF | James Wood | Was | Cle(3) StL(3) |
| DH (OF,1B) | Tyler Soderstrom | Oak | Sea(3) NYA(3) |
| Position | 1st Backup | Team | Opponents |
| C | Joey Bart | Pit | @StL(3) Atl(3) |
| 1B | Yandy Diaz | TB | Phi(3) Mil(3) |
| 2B | Wilmer Flores | SF | @ChN(3) @Min(3) |
| SS | Jeremy Pena | Hou | @Mil(3) Cin(3) |
| 3B (OF,SS) | Jose Caballero | TB | Phi(3) Mil(3) |
| OF | Wyatt Langford | Tex | @Bos(3) @Det(3) |
| DH | Kerry Carpenter | Det | @Col(3) Tex(3) |
| Position | 2nd Backup | Team | Opponents |
| DH (1B,OF) | Pavin Smith | Ari | NYN(3) LAD(4) |
| Position | 3rd Backup | Team | Opponents |
| OF | Lourdes Gurriel | Ari | NYN(3) LAD(4) |
| Position | Bench | Team | Opponents |
| 2B | Luke Keaschall | Min | Bal(3) SF(3) |
| SS | Marcelo Mayer | Bos | Tex(3) @KC(3) |
| OF | Tyler O'Neill | Bal | @Min(3) @LAA(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Kodai Senga | NYN | @Ari(3) ChN(3) | This Wednesday at Ari (Merrill Kelly) |
| 2nd SP | Kris Bubic | KC | ChA(4) Bos(3) | This Thursday vs ChA (Davis Martin) |
| 3rd SP | Nick Lodolo | Cin | @Atl(4) @Hou(3) | This Thursday at Atl (Spencer Schwellenbach) |
| 4th SP | Bryce Miller | Sea | @Oak(3) Tor(3) | This Monday at Oak (Luis Severino) |
| 5th SP | JP Sears | Oak | Sea(3) NYA(3) | This Saturday vs NYA (Will Warren) |
| 6th SP | Jack Flaherty | Det | @Col(3) Tex(3) | This Friday vs Tex (Pat Corbin) |
| 7th SP | Logan Henderson | Mil | Hou(3) @TB(3) | Last Pitched Sunday April 20th |
| 1st RP | Josh Hader | Hou | @Mil(3) Cin(3) | Last Pitched Tuesday April 29th |
| 2nd RP | Emilio Pagan | Cin | @Atl(4) @Hou(3) | Last Pitched Friday May 2nd |
| 3rd RP | Devin Williams | NYA | SD(3) @Oak(3) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Opponents |
| 3B (2B,OF) | Dylan Moore | Sea | @Oak(3) Tor(3) |
| SP | Richard Fitts | Bos | Tex(3) @KC(3) |
| SP | George Kirby | Sea | @Oak(3) Tor(3) |