| Position | Starters | Team | Opponents |
| C | Adley Rutschman | Bal | @Min(3) @LAA(3) |
| 1B | Vladimir Guerrero Jr. | Tor | @LAA(3) @Sea(3) |
| 2B | Gleyber Torres | Det | @Col(3) Tex(3) |
| SS | Bobby Witt Jr. | KC | ChA(4) Bos(3) |
| 3B | Matt Chapman | SF | @ChN(3) @Min(3) |
| OF | Nick Castellanos | Phi | @TB(3) @Cle(3) |
| OF | TJ Friedl | Cin | @Atl(4) @Hou(3) |
| DH (OF,2B) | Jose Altuve | Hou | @Mil(3) Cin(3) |
| Position | 1st Backup | Team | Opponents |
| C | Gabriel Moreno | Ari | NYN(3) LAD(4) |
| 1B (OF) | Ryan O'Hearn | Bal | @Min(3) @LAA(3) |
| 2B (3B,SS) | Gabriel Arias | Cle | @Was(3) Phi(3) |
| SS | Jeremy Pena | Hou | @Mil(3) Cin(3) |
| 3B (2B,OF) | Maikel Garcia | KC | ChA(4) Bos(3) |
| OF | Sal Frelick | Mil | Hou(3) @TB(3) |
| DH | Anthony Santander | Tor | @LAA(3) @Sea(3) |
| Position | 2nd Backup | Team | Opponents |
| OF (1B) | Spencer Steer | Cin | @Atl(4) @Hou(3) |
| DH | Taylor Ward | LAA | Tor(3) Bal(3) |
| Position | 3rd Backup | Team | Opponents |
| OF | Andrew Benintendi | ChA | @KC(4) Mia(3) |
| Position | Bench | Team | Opponents |
| 1B | Luis Arraez | SD | @NYA(3) @Col(3) |
| SS | JJ Wetherholt | StL | Pit(3) @Was(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Kevin Gausman | Tor | @LAA(3) @Sea(3) | This Friday at Sea (Luis Castillo) |
| 2nd SP | Tarik Skubal | Det | @Col(3) Tex(3) | This Thursday at Col (Antonio Senzatela) |
| 3rd SP | Mitch Keller | Pit | @StL(3) Atl(3) | This Wednesday at StL (Matthew Liberatore) |
| 4th SP | Luis Castillo | Sea | @Oak(3) Tor(3) | This Friday vs Tor (Kevin Gausman) |
| 5th SP | Jack Leiter | Tex | @Bos(3) @Det(3) | This Thursday at Bos (Brayan Bello) |
| 6th SP | Bailey Ober | Min | Bal(3) SF(3) | This Friday vs SF (Jordan Hicks) |
| 7th SP | Bubba Chandler | Pit | @StL(3) Atl(3) | Has Not Played Yet |
| 8th SP (RP) | Ben Casparius | LAD | @Mia(3) @Ari(4) | Last Pitched Sunday April 27th |
| 1st RP | Andres Munoz | Sea | @Oak(3) Tor(3) | Last Pitched Tuesday April 29th |
| 2nd RP | Ryan Helsley | StL | Pit(3) @Was(3) | Last Pitched Friday May 2nd |
| 3rd RP | David Bednar | Pit | @StL(3) Atl(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Opponents |
| SP | Logan Gilbert | Sea | @Oak(3) Tor(3) |
| OF | Austin Hays | Cin | @Atl(4) @Hou(3) |
| SP | Clayton Kershaw | LAD | @Mia(3) @Ari(4) |