| Position | Starters | Team | Opponents |
| C | Sean Murphy | Atl | Cin(4) @Pit(3) |
| 1B | Bryce Harper | Phi | @TB(3) @Cle(3) |
| SS | Elly De La Cruz | Cin | @Atl(4) @Hou(3) |
| 3B | Manny Machado | SD | @NYA(3) @Col(3) |
| OF | Teoscar Hernández | LAD | @Mia(3) @Ari(4) |
| OF | Luis Robert Jr. | ChA | @KC(4) Mia(3) |
| OF | Kyle Tucker | ChN | SF(3) @NYN(3) |
| DH | Yandy Diaz | TB | Phi(3) Mil(3) |
| Position | 1st Backup | Team | Opponents |
| C | Ryan Jeffers | Min | Bal(3) SF(3) |
| 1B | Jonathan Aranda | TB | Phi(3) Mil(3) |
| 2B (3B) | Brooks Lee | Min | Bal(3) SF(3) |
| SS | Geraldo Perdomo | Ari | NYN(3) LAD(4) |
| 3B (OF) | Cam Smith | Hou | @Mil(3) Cin(3) |
| OF | Mickey Moniak | Col | Det(3) SD(3) |
| DH | Ceddanne Rafaela | Bos | Tex(3) @KC(3) |
| Position | 2nd Backup | Team | Opponents |
| 1B | Bryce Eldridge | SF | @ChN(3) @Min(3) |
| 2B | Brendan Rodgers | Hou | @Mil(3) Cin(3) |
| OF | Michael Conforto | LAD | @Mia(3) @Ari(4) |
| DH | Nick Kurtz | Oak | Sea(3) NYA(3) |
| Pitching Staff Alignment |
| 5 Starts, 3 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Corbin Burnes | Ari | NYN(3) LAD(4) | This Monday vs NYN (Griffin Canning) |
| 2nd SP | Zac Gallen | Ari | NYN(3) LAD(4) | This Tuesday vs NYN (David Peterson) |
| 3rd SP | Matt Boyd | ChN | SF(3) @NYN(3) | This Monday vs SF (Landen Roupp) |
| 4th SP | JP Sears | Oak | Sea(3) NYA(3) | Last Pitched Monday April 28th |
| 5th SP | Tyler Anderson | LAA | Tor(3) Bal(3) | This Tuesday vs Tor (TBD) |
| 6th SP | Michael Wacha | KC | ChA(4) Bos(3) | This Wednesday vs ChA (Jonathan Cannon) |
| 7th SP | Reese Olson | Det | @Col(3) Tex(3) | Last Pitched Tuesday April 29th |
| 8th SP | Tanner Houck | Bos | Tex(3) @KC(3) | This Wednesday vs Tex (Tyler Mahle) |
| 9th SP | Yusei Kikuchi | LAA | Tor(3) Bal(3) | This Wednesday vs Tor (Jose Berrios) |
| 1st RP | Carlos Estevez | KC | ChA(4) Bos(3) | Last Pitched Wednesday April 30th |
| 2nd RP | José Alvarado | Phi | @TB(3) @Cle(3) | Last Pitched Friday May 2nd |
| 3rd RP | Ryan Pressly | ChN | SF(3) @NYN(3) | Last Pitched Thursday May 1st |
| Position | Injured List | Team | Opponents |
| 2B | Ketel Marte | Ari | NYN(3) LAD(4) |