| Position | Starters | Team | Opponents |
| C | Agustin Ramirez | Mia | LAD(3) @ChA(3) |
| 1B | Ben Rice | NYA | SD(3) @Oak(3) |
| 2B (OF) | Kristian Campbell | Bos | Tex(3) @KC(3) |
| 3B | Austin Riley | Atl | Cin(4) @Pit(3) |
| OF | Lawrence Butler | Oak | Sea(3) NYA(3) |
| OF | Dylan Crews | Was | Cle(3) StL(3) |
| OF | Kyle Schwarber | Phi | @TB(3) @Cle(3) |
| DH (OF,1B) | Tyler Soderstrom | Oak | Sea(3) NYA(3) |
| Position | 1st Backup | Team | Opponents |
| C | Yainer Diaz | Hou | @Mil(3) Cin(3) |
| 1B | Michael Busch | ChN | SF(3) @NYN(3) |
| 2B (OF) | Gavin Lux | Cin | @Atl(4) @Hou(3) |
| SS (2B) | Adael Amador | Col | Det(3) SD(3) |
| 3B (OF) | Zach Dezenzo | Hou | @Mil(3) Cin(3) |
| OF (C) | Hunter Goodman | Col | Det(3) SD(3) |
| DH | Vinnie Pasquantino | KC | ChA(4) Bos(3) |
| Position | 2nd Backup | Team | Opponents |
| OF | Trent Grisham | NYA | SD(3) @Oak(3) |
| DH | Christopher Morel | TB | Phi(3) Mil(3) |
| Pitching Staff Alignment |
| 10 Starts, 0 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Luis Ortiz | Cle | @Was(3) Phi(3) | This Monday at Was (Jake Irvin) |
| 2nd SP | Shane Smith | ChA | @KC(4) Mia(3) | This Monday at KC (Cole Ragans) |
| 3rd SP | Pablo Lopez | Min | Bal(3) SF(3) | This Tuesday vs Bal (Cade Povich) |
| 4th SP | Griffin Canning | NYN | @Ari(3) ChN(3) | This Monday at Ari (Corbin Burnes) |
| 5th SP | Freddy Peralta | Mil | Hou(3) @TB(3) | Last Pitched Tuesday April 29th |
| 6th SP | Andrew Abbott | Cin | @Atl(4) @Hou(3) | This Tuesday at Atl (Chris Sale) |
| 7th SP | Clay Holmes | NYN | @Ari(3) ChN(3) | This Friday vs ChN (Jameson Taillon) |
| 8th SP | Robbie Ray | SF | @ChN(3) @Min(3) | This Wednesday at ChN (Ben Brown) |
| 9th SP | Ranger Suarez | Phi | @TB(3) @Cle(3) | Has Not Played Yet |
| 10th SP | Spencer Schwellenbach | Atl | Cin(4) @Pit(3) | This Thursday vs Cin (Nick Lodolo) |
| 11th SP | Zebby Matthews | Min | Bal(3) SF(3) | Has Not Played Yet |
| 12th SP | AJ Smith-Shawver | Atl | Cin(4) @Pit(3) | This Monday vs Cin (Brady Singer) |
| 13th SP (RP) | Ryan Gusto | Hou | @Mil(3) Cin(3) | Last Pitched Tuesday April 29th |
| Position | Injured List | Team | Opponents |
| OF | Tyler O'Neill | Bal | @Min(3) @LAA(3) |
| SS | Corey Seager | Tex | @Bos(3) @Det(3) |
| SP | Jared Jones | Pit | @StL(3) Atl(3) |