| Position | Starters | Team | Opponents |
| C | Shea Langeliers | Oak | Sea(3) NYA(3) |
| 1B | Pete Alonso | NYN | @Ari(3) ChN(3) |
| 2B | Wilmer Flores | SF | @ChN(3) @Min(3) |
| SS | Gunnar Henderson | Bal | @Min(3) @LAA(3) |
| 3B | Connor Norby | Mia | LAD(3) @ChA(3) |
| OF | Cedric Mullins II | Bal | @Min(3) @LAA(3) |
| OF | Brent Rooker | Oak | Sea(3) NYA(3) |
| OF | Fernando Tatis Jr. | SD | @NYA(3) @Col(3) |
| DH | Aaron Judge | NYA | SD(3) @Oak(3) |
| Position | 1st Backup | Team | Opponents |
| 1B | Ryan Mountcastle | Bal | @Min(3) @LAA(3) |
| 2B | Nolan Gorman | StL | Pit(3) @Was(3) |
| SS | Trevor Story | Bos | Tex(3) @KC(3) |
| 3B | Ke'Bryan Hayes | Pit | @StL(3) Atl(3) |
| OF | Julio Rodriguez | Sea | @Oak(3) Tor(3) |
| DH (1B,OF) | Gavin Sheets | SD | @NYA(3) @Col(3) |
| Position | 2nd Backup | Team | Opponents |
| OF | Andrew McCutchen | Pit | @StL(3) Atl(3) |
| Position | 3rd Backup | Team | Opponents |
| 3B | Coby Mayo | Bal | @Min(3) @LAA(3) |
| Position | Bench | Team | Opponents |
| C | Miguel Amaya | ChN | SF(3) @NYN(3) |
| Pitching Staff Alignment |
| 10 Starts, 0 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Hunter Brown | Hou | @Mil(3) Cin(3) | This Friday vs Cin (Nick Martinez) |
| 2nd SP | Brady Singer | Cin | @Atl(4) @Hou(3) | This Monday at Atl (AJ Smith-Shawver) |
| 3rd SP | Nick Pivetta | SD | @NYA(3) @Col(3) | Last Pitched Tuesday April 29th |
| 4th SP | Sonny Gray | StL | Pit(3) @Was(3) | This Friday at Was (Trevor Williams) |
| 5th SP | Nathan Eovaldi | Tex | @Bos(3) @Det(3) | This Tuesday at Bos (Sean Newcomb) |
| 6th SP | Tyler Mahle | Tex | @Bos(3) @Det(3) | This Wednesday at Bos (Tanner Houck) |
| 7th SP | Drew Rasmussen | TB | Phi(3) Mil(3) | This Tuesday vs Phi (Zack Wheeler) |
| 8th SP | Walker Buehler | Bos | Tex(3) @KC(3) | Last Pitched Saturday April 26th |
| 9th SP | Jeffrey Springs | Oak | Sea(3) NYA(3) | This Tuesday vs Sea (Emerson Hancock) |
| 10th SP | Emerson Hancock | Sea | @Oak(3) Tor(3) | This Tuesday at Oak (Jeffrey Springs) |
| 11th SP | Hayden Wesneski | Hou | @Mil(3) Cin(3) | This Tuesday at Mil (Chad Patrick) |
| 12th SP | Lance McCullers | Hou | @Mil(3) Cin(3) | Has Not Played Yet |
| 13th SP | Mike Lorenzen | KC | ChA(4) Bos(3) | This Friday vs Bos (TBD) |
| Position | Injured List | Team | Opponents |
| SP | Blake Snell | LAD | @Mia(3) @Ari(4) |
| SP | Yu Darvish | SD | @NYA(3) @Col(3) |
| SP | Grayson Rodriguez | Bal | @Min(3) @LAA(3) |