| Position | Starters | Team | Opponents |
| C | Shea Langeliers | Oak | Sea(3) NYA(3) |
| 1B | Vinnie Pasquantino | KC | ChA(4) Bos(3) |
| 2B | Jazz Chisholm Jr. | NYA | SD(3) @Oak(3) |
| SS | Bobby Witt Jr. | KC | ChA(4) Bos(3) |
| 3B | Austin Riley | Atl | Cin(4) @Pit(3) |
| OF | Lars Nootbaar | StL | Pit(3) @Was(3) |
| OF | Luis Robert Jr. | ChA | @KC(4) Mia(3) |
| OF | Anthony Santander | Tor | @LAA(3) @Sea(3) |
| DH | Lawrence Butler | Oak | Sea(3) NYA(3) |
| Position | 1st Backup | Team | Opponents |
| C | Alejandro Kirk | Tor | @LAA(3) @Sea(3) |
| 1B | Ryan Mountcastle | Bal | @Min(3) @LAA(3) |
| 2B | Luis Garcia | Was | Cle(3) StL(3) |
| SS | Zach Neto | LAA | Tor(3) Bal(3) |
| 3B | Nolan Arenado | StL | Pit(3) @Was(3) |
| OF | Alex Verdugo | Atl | Cin(4) @Pit(3) |
| DH | Ty France | Min | Bal(3) SF(3) |
| Position | 2nd Backup | Team | Opponents |
| OF | Michael Conforto | LAD | @Mia(3) @Ari(4) |
| DH (3B,OF,SS) | Jose Caballero | TB | Phi(3) Mil(3) |
| Position | Bench | Team | Opponents |
| OF | Colton Cowser | Bal | @Min(3) @LAA(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Tarik Skubal | Det | @Col(3) Tex(3) | This Thursday at Col (Antonio Senzatela) |
| 2nd SP | Chris Sale | Atl | Cin(4) @Pit(3) | This Tuesday vs Cin (Andrew Abbott) |
| 3rd SP | Bailey Ober | Min | Bal(3) SF(3) | This Friday vs SF (Jordan Hicks) |
| 4th SP | Robbie Ray | SF | @ChN(3) @Min(3) | This Wednesday at ChN (Ben Brown) |
| 5th SP | Seth Lugo | KC | ChA(4) Bos(3) | This Tuesday vs ChA (Sean Burke) |
| 6th SP | Tony Gonsolin | LAD | @Mia(3) @Ari(4) | This Tuesday at Mia (Cal Quantrill) |
| 7th SP | Griffin Canning | NYN | @Ari(3) ChN(3) | This Monday at Ari (Corbin Burnes) |
| 8th SP | Tomoyuki Sugano | Bal | @Min(3) @LAA(3) | This Thursday at Min (Joe Ryan) |
| 9th SP | Simeon Woods Richardson | Min | Bal(3) SF(3) | This Wednesday vs Bal (Dean Kremer) |
| 10th SP | Nestor Cortes Jr. | Mil | Hou(3) @TB(3) | Last Pitched Thursday April 3rd |
| 1st RP | Ryan Pressly | ChN | SF(3) @NYN(3) | Last Pitched Thursday May 1st |
| 2nd RP | Shelby Miller | Ari | NYN(3) LAD(4) | Last Pitched Thursday May 1st |
| Position | Injured List | Team | Opponents |
| SP | Yu Darvish | SD | @NYA(3) @Col(3) |
| SP | Luis Gil | NYA | SD(3) @Oak(3) |
| SP | Grayson Rodriguez | Bal | @Min(3) @LAA(3) |