| Position | Starters | Team | Opponents |
| C | Carson Kelly | ChN | SF(3) @NYN(3) |
| 1B | Bryce Harper | Phi | @TB(3) @Cle(3) |
| 2B (OF) | Tim Tawa | Ari | NYN(3) LAD(4) |
| SS | Anthony Volpe | NYA | SD(3) @Oak(3) |
| 3B | Rafael Devers | Bos | Tex(3) @KC(3) |
| OF | Brent Rooker | Oak | Sea(3) NYA(3) |
| OF | Mike Trout | LAA | Tor(3) Bal(3) |
| OF | Mike Yastrzemski | SF | @ChN(3) @Min(3) |
| DH | Ben Rice | NYA | SD(3) @Oak(3) |
| Position | 1st Backup | Team | Opponents |
| C (OF) | Hunter Goodman | Col | Det(3) SD(3) |
| 1B (OF) | Ryan O'Hearn | Bal | @Min(3) @LAA(3) |
| 2B (SS) | Jackson Holliday | Bal | @Min(3) @LAA(3) |
| SS | Jacob Wilson | Oak | Sea(3) NYA(3) |
| 3B | Josh Jung | Tex | @Bos(3) @Det(3) |
| OF | Riley Greene | Det | @Col(3) Tex(3) |
| DH (3B,OF,2B) | Zach McKinstry | Det | @Col(3) Tex(3) |
| Position | 2nd Backup | Team | Opponents |
| C | Keibert Ruiz | Was | Cle(3) StL(3) |
| Position | Bench | Team | Opponents |
| 1B | Jac Caglianone | KC | ChA(4) Bos(3) |
| OF | Trevor Larnach | Min | Bal(3) SF(3) |
| OF | Andy Pages | LAD | @Mia(3) @Ari(4) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Bryan Woo | Sea | @Oak(3) Tor(3) | This Wednesday at Oak (Gunnar Hoglund) |
| 2nd SP | Kodai Senga | NYN | @Ari(3) ChN(3) | This Wednesday at Ari (Merrill Kelly) |
| 3rd SP | Nick Lodolo | Cin | @Atl(4) @Hou(3) | This Thursday at Atl (Spencer Schwellenbach) |
| 4th SP | David Peterson | NYN | @Ari(3) ChN(3) | This Tuesday at Ari (Zac Gallen) |
| 5th SP | Jeffrey Springs | Oak | Sea(3) NYA(3) | This Tuesday vs Sea (Emerson Hancock) |
| 6th SP (RP) | Ryan Gusto | Hou | @Mil(3) Cin(3) | Last Pitched Tuesday April 29th |
| 7th SP | Pat Corbin | Tex | @Bos(3) @Det(3) | This Friday at Det (Jack Flaherty) |
| 8th SP | Justin Verlander | SF | @ChN(3) @Min(3) | This Tuesday at ChN (Colin Rea) |
| 1st RP | Felix Bautista | Bal | @Min(3) @LAA(3) | Last Pitched Friday May 2nd |
| 2nd RP | Andres Munoz | Sea | @Oak(3) Tor(3) | Last Pitched Tuesday April 29th |
| Position | Injured List | Team | Opponents |
| 1B | Christian Encarnacion-Strand | Cin | @Atl(4) @Hou(3) |
| SP | Walker Buehler | Bos | Tex(3) @KC(3) |
| SP | Max Scherzer | Tor | @LAA(3) @Sea(3) |