| Position | Starters | Team | Opponents |
| C | J.T. Realmuto | Phi | @TB(3) @Cle(3) |
| 1B | Michael Busch | ChN | SF(3) @NYN(3) |
| 2B (SS,OF) | Brendan Donovan | StL | Pit(3) @Was(3) |
| SS | Xavier Edwards | Mia | LAD(3) @ChA(3) |
| 3B | Matt Chapman | SF | @ChN(3) @Min(3) |
| OF | Teoscar Hernández | LAD | @Mia(3) @Ari(4) |
| OF | Juan Soto | NYN | @Ari(3) ChN(3) |
| OF | Fernando Tatis Jr. | SD | @NYA(3) @Col(3) |
| DH (1B,OF) | Spencer Steer | Cin | @Atl(4) @Hou(3) |
| Position | 1st Backup | Team | Opponents |
| C | Ryan Jeffers | Min | Bal(3) SF(3) |
| 1B | Christian Walker | Hou | @Mil(3) Cin(3) |
| 2B (3B) | Luis Rengifo | LAA | Tor(3) Bal(3) |
| SS | J.P. Crawford | Sea | @Oak(3) Tor(3) |
| 3B | Connor Norby | Mia | LAD(3) @ChA(3) |
| OF | Brenton Doyle | Col | Det(3) SD(3) |
| DH | Lourdes Gurriel | Ari | NYN(3) LAD(4) |
| Position | Bench | Team | Opponents |
| 1B | Nolan Schanuel | LAA | Tor(3) Bal(3) |
| SS (3B) | Oswald Peraza | NYA | SD(3) @Oak(3) |
| DH (3B,OF,2B) | Jonathan India | KC | ChA(4) Bos(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Zack Wheeler | Phi | @TB(3) @Cle(3) | This Tuesday at TB (Drew Rasmussen) |
| 2nd SP | Corbin Burnes | Ari | NYN(3) LAD(4) | This Monday vs NYN (Griffin Canning) |
| 3rd SP | Spencer Schwellenbach | Atl | Cin(4) @Pit(3) | This Thursday vs Cin (Nick Lodolo) |
| 4th SP | Sandy Alcantara | Mia | LAD(3) @ChA(3) | This Monday vs LAD (TBD) |
| 5th SP | Bowden Francis | Tor | @LAA(3) @Sea(3) | Last Pitched Tuesday April 29th |
| 6th SP | Kris Bubic | KC | ChA(4) Bos(3) | This Thursday vs ChA (Davis Martin) |
| 7th SP | Ronel Blanco | Hou | @Mil(3) Cin(3) | This Monday at Mil (Tobias Myers) |
| 8th SP | Grant Holmes | Atl | Cin(4) @Pit(3) | This Wednesday vs Cin (Hunter Greene) |
| 9th SP | Clarke Schmidt | NYA | SD(3) @Oak(3) | This Friday at Oak (Osvaldo Bido) |
| 10th SP | Luis Ortiz | Cle | @Was(3) Phi(3) | This Monday at Was (Jake Irvin) |
| 1st RP | Raisel Iglesias | Atl | Cin(4) @Pit(3) | Last Pitched Monday April 28th |
| 2nd RP | Jhoan Duran | Min | Bal(3) SF(3) | Last Pitched Thursday May 1st |
| Position | Injured List | Team | Opponents |
| 3B | Matt Vierling | Det | @Col(3) Tex(3) |
| SP | Sean Manaea | NYN | @Ari(3) ChN(3) |