| Position | Starters | Team | Opponents |
| C (1B,C) | Salvador Perez | KC | ChA(4) Bos(3) |
| 1B | Nathaniel Lowe | Was | Cle(3) StL(3) |
| 2B | Brandon Lowe | TB | Phi(3) Mil(3) |
| SS | Gunnar Henderson | Bal | @Min(3) @LAA(3) |
| 3B | Manny Machado | SD | @NYA(3) @Col(3) |
| OF | Oneil Cruz | Pit | @StL(3) Atl(3) |
| OF | Riley Greene | Det | @Col(3) Tex(3) |
| OF | Steven Kwan | Cle | @Was(3) Phi(3) |
| DH | Alec Bohm | Phi | @TB(3) @Cle(3) |
| Position | 1st Backup | Team | Opponents |
| C | Alejandro Kirk | Tor | @LAA(3) @Sea(3) |
| 1B | Anthony Rizzo | NYA | SD(3) @Oak(3) |
| 2B | Brice Turang | Mil | Hou(3) @TB(3) |
| 3B | Junior Caminero | TB | Phi(3) Mil(3) |
| OF (1B) | Luke Raley | Sea | @Oak(3) Tor(3) |
| DH (SS,3B,2B) | Willi Castro | Min | Bal(3) SF(3) |
| Position | 2nd Backup | Team | Opponents |
| OF | Josh Lowe | TB | Phi(3) Mil(3) |
| DH | Heston Kjerstad | Bal | @Min(3) @LAA(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Zac Gallen | Ari | NYN(3) LAD(4) | This Tuesday vs NYN (David Peterson) |
| 2nd SP | Paul Skenes | Pit | @StL(3) Atl(3) | This Tuesday at StL (Steven Matz) |
| 3rd SP | Seth Lugo | KC | ChA(4) Bos(3) | This Tuesday vs ChA (Sean Burke) |
| 4th SP | Yu Darvish | SD | @NYA(3) @Col(3) | Has Not Played Yet |
| 5th SP | Yoshinobu Yamamoto | LAD | @Mia(3) @Ari(4) | This Thursday at Ari (Brandon Pfaadt) |
| 6th SP | Nestor Cortes Jr. | Mil | Hou(3) @TB(3) | Last Pitched Thursday April 3rd |
| 7th SP | Jeffrey Springs | Oak | Sea(3) NYA(3) | This Tuesday vs Sea (Emerson Hancock) |
| 8th SP | Drew Rasmussen | TB | Phi(3) Mil(3) | This Tuesday vs Phi (Zack Wheeler) |
| 9th SP | Grant Holmes | Atl | Cin(4) @Pit(3) | This Wednesday vs Cin (Hunter Greene) |
| 10th SP | Dustin May | LAD | @Mia(3) @Ari(4) | Last Pitched Monday April 28th |
| 1st RP | Edwin Diaz | NYN | @Ari(3) ChN(3) | Last Pitched Saturday April 26th |
| 2nd RP | Kenley Jansen | LAA | Tor(3) Bal(3) | Last Pitched Friday May 2nd |
| 3rd RP | Jason Adam | SD | @NYA(3) @Col(3) | Last Pitched Wednesday April 30th |
| 4th RP | Griffin Jax | Min | Bal(3) SF(3) | Last Pitched Thursday May 1st |