| Position | Starters | Team | Opponents |
| C | Will Smith | LAD | @Mia(3) @Ari(4) |
| 1B | Luis Arraez | SD | @NYA(3) @Col(3) |
| 2B (OF) | Jose Altuve | Hou | @Mil(3) Cin(3) |
| SS | Corey Seager | Tex | @Bos(3) @Det(3) |
| 3B | Jose Ramirez | Cle | @Was(3) Phi(3) |
| OF | Jackson Chourio | Mil | Hou(3) @TB(3) |
| OF | Brenton Doyle | Col | Det(3) SD(3) |
| OF | Jackson Merrill | SD | @NYA(3) @Col(3) |
| DH | Max Muncy | LAD | @Mia(3) @Ari(4) |
| Position | 1st Backup | Team | Opponents |
| C | Yainer Diaz | Hou | @Mil(3) Cin(3) |
| 3B | Ke'Bryan Hayes | Pit | @StL(3) Atl(3) |
| OF | Lourdes Gurriel | Ari | NYN(3) LAD(4) |
| DH | Ceddanne Rafaela | Bos | Tex(3) @KC(3) |
| Position | 2nd Backup | Team | Opponents |
| OF | Joc Pederson | Tex | @Bos(3) @Det(3) |
| Position | Bench | Team | Opponents |
| OF | Evan Carter | Tex | @Bos(3) @Det(3) |
| OF | Giancarlo Stanton | NYA | SD(3) @Oak(3) |
| Pitching Staff Alignment |
| 10 Starts, 0 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Shota Imanaga | ChN | SF(3) @NYN(3) | Last Pitched Tuesday April 29th |
| 2nd SP | Luis Castillo | Sea | @Oak(3) Tor(3) | This Friday vs Tor (Kevin Gausman) |
| 3rd SP | Hunter Greene | Cin | @Atl(4) @Hou(3) | This Wednesday at Atl (Grant Holmes) |
| 4th SP | Kodai Senga | NYN | @Ari(3) ChN(3) | This Wednesday at Ari (Merrill Kelly) |
| 5th SP | Sandy Alcantara | Mia | LAD(3) @ChA(3) | This Monday vs LAD (TBD) |
| 6th SP | Nathan Eovaldi | Tex | @Bos(3) @Det(3) | This Tuesday at Bos (Sean Newcomb) |
| 7th SP | Jesus Luzardo | Phi | @TB(3) @Cle(3) | This Thursday at TB (Ryan Pepiot) |
| 8th SP | Reese Olson | Det | @Col(3) Tex(3) | Last Pitched Tuesday April 29th |
| 9th SP | Walker Buehler | Bos | Tex(3) @KC(3) | Last Pitched Saturday April 26th |
| 10th SP | Luis Severino | Oak | Sea(3) NYA(3) | This Monday vs Sea (Bryce Miller) |
| 11th SP | DJ Herz | Was | Cle(3) StL(3) | Has Not Played Yet |
| 1st RP | Felix Bautista | Bal | @Min(3) @LAA(3) | Last Pitched Friday May 2nd |
| 2nd RP | Ryan Pressly | ChN | SF(3) @NYN(3) | Last Pitched Thursday May 1st |
| 3rd RP | Aroldis Chapman | Bos | Tex(3) @KC(3) | Last Pitched Wednesday April 30th |