| Round | Overall | Player |
|---|---|---|
| 1 | 7th | 1B Ryan Howard Phi |
| 2 | 18th | 3B David Wright NYN |
| 3 | 31st | 1B Justin Morneau Min |
| 4 | 42nd | 2B Robinson Cano NYA |
| 5 | 55th | OF Manny Ramirez ChA |
| 6 | 66th | SP Josh Johnson Fla |
| 7 | 79th | SP Tommy Hanson Atl |
| 8 | 90th | OF Jason Heyward ATL |
| 9 | 103rd | SS Jason Bartlett SD |
| 10 | 114th | OF Andrew McCutchen Pit |
| 11 | 127th | SP Matt Garza ChN |
| 12 | 138th | DH Jorge Posada NYA |
| 13 | 151st | SP Kevin Slowey Min |
| 14 | 162nd | DH David Ortiz Bos |
| 15 | 175th | SP Johnny Cueto Cin |
| 16 | 186th | SP Philip Hughes NYA |
| 17 | 199th | RP Trevor Hoffman Ret |
| 18 | 210th | OF Garrett Jones Pit |
| 19 | 223rd | SP Homer Bailey Cin |
| 20 | 234th | OF Vernon Wells Tor |
| 21 | 247th | RP Chris Perez Cle |
| 22 | 258th | 1B Matt LaPorta Cle |
| 23 | 271st | SS Everth Cabrera SD |
| 24 | 282nd | SP Ricky Romero Tor |
| 25 | 295th | 3B Chase Headley SD |
| 26 | 306th | C Jarrod Saltalamacchia Bos |