| Round | Overall | Player |
|---|---|---|
| 1 | 9th | 1B Prince Fielder Mil |
| 2 | 16th | SP Felix Hernandez Sea |
| 3 | 33rd | 3B Ryan Zimmerman Was |
| 4 | 40th | OF Jacoby Ellsbury Bos |
| 5 | 57th | SP Cliff Lee Phi |
| 6 | 64th | 2B Howie Kendrick LAA |
| 7 | 81st | 1B Billy Butler KC |
| 8 | 88th | SS Stephen Drew Ari |
| 9 | 105th | RP Francisco Cordero Cin |
| 10 | 112th | OF Adam Jones Bal |
| 11 | 129th | OF Alfonso Soriano ChN |
| 12 | 136th | SP Tim Hudson Atl |
| 13 | 153rd | C Miguel Montero Ari |
| 14 | 160th | SP Rich Harden Oak |
| 15 | 177th | OF Johnny Damon Det |
| 16 | 184th | SP Mark Buehrle ChA |
| 17 | 201st | OF Franklin Gutierrez Sea |
| 18 | 208th | OF Denard Span Min |
| 19 | 225th | SP Mat Latos SD |
| 20 | 232nd | 1B Todd Helton Col |
| 21 | 249th | RP Brandon Lyon Hou |
| 22 | 256th | SP Trevor Cahill Oak |
| 23 | 273rd | 3B Brandon Wood LAA |
| 24 | 280th | RP Matt Lindstrom Col |
| 25 | 297th | SP Chris Tillman Bal |
| 26 | 304th | C Ramon Hernandez Cin |