| Round | Overall | Player |
|---|---|---|
| 1 | 10th | 3B Evan Longoria TB |
| 2 | 15th | 1B Adrian Gonzalez Bos |
| 3 | 34th | OF Matt Holliday StL |
| 4 | 39th | SP Justin Verlander Det |
| 5 | 58th | SP Cole Hamels Phi |
| 6 | 63rd | OF Jayson Werth Was |
| 7 | 82nd | OF Andrew McCutchen Pit |
| 8 | 87th | RP Jon Papelbon Phi |
| 9 | 106th | SP Max Scherzer Det |
| 10 | 111th | SS Stephen Drew Ari |
| 11 | 130th | 2B Aaron Hill Ari |
| 12 | 135th | SP Ryan Dempster ChN |
| 13 | 154th | SP John Lackey Bos |
| 14 | 159th | C Kurt Suzuki Oak |
| 15 | 178th | SP Brandon Morrow Tor |
| 16 | 183rd | 1B Derrek Lee Pit |
| 17 | 202nd | 1B Adam Lind Tor |
| 18 | 207th | OF Raul Ibanez Phi |
| 19 | 226th | SP Bronson Arroyo Cin |
| 20 | 231st | SS Miguel Tejada SF |
| 21 | 250th | 3B Chase Headley SD |
| 22 | 255th | SP A.J. Burnett NYA |
| 23 | 274th | OF Marlon Byrd ChN |
| 24 | 279th | 2B Omar Infante Fla |
| 25 | 298th | 2B Sean Rodriguez TB |
| 26 | 303rd | SP Randy Wolf Mil |
| 27 | 322nd | SP Erik Bedard Sea |
| 28 | 327th | SP Daisuke Matsuzaka Bos |
| 29 | 346th | C Chris Snyder Pit |