| Round | Overall | Player |
|---|---|---|
| 1 | 1st | 1B Albert Pujols LAA |
| 2 | 24th | OF Matt Holliday StL |
| 3 | 25th | OF Nelson Cruz Tex |
| 4 | 48th | 2B Rickie Weeks Mil |
| 5 | 49th | SP Josh Johnson Fla |
| 6 | 72nd | 3B Pedro Alvarez Pit |
| 7 | 73rd | DH David Ortiz Bos |
| 8 | 96th | OF Alexis Rios ChA |
| 9 | 97th | SS Alexei Ramirez ChA |
| 10 | 120th | SP Ricky Romero Tor |
| 11 | 121st | OF Jacoby Ellsbury Bos |
| 12 | 144th | SP Carl Pavano Min |
| 13 | 145th | RP Francisco Rodriguez Mil |
| 14 | 168th | OF Logan Morrison Fla |
| 15 | 169th | OF Travis Snider Tor |
| 16 | 192nd | SP Gavin Floyd ChA |
| 17 | 193rd | RP Matt Thornton ChA |
| 18 | 216th | SP Mark Buehrle Fla |
| 19 | 217th | SP A.J. Burnett NYA |
| 20 | 240th | OF Andres Torres NYN |
| 21 | 241st | 3B Chipper Jones Atl |
| 22 | 264th | 1B Mark Trumbo LAA |
| 23 | 265th | SP Travis Wood ChN |
| 24 | 288th | C Josh Thole NYN |
| 25 | 289th | SS Yuniesky Betancourt KC |
| 26 | 312th | OF Domonic Brown Phi |
| 27 | 313th | 2B Freddy Sanchez SF |
| 28 | 336th | 1B Chris Davis Bal |
| 29 | 337th | C Ryan Hanigan Cin |