| Round | Overall | Player |
|---|---|---|
| 1 | 11th | OF Carlos Gonzalez Col |
| 2 | 14th | SP Roy Halladay Phi |
| 3 | 35th | SP Cliff Lee Phi |
| 4 | 38th | SP Justin Verlander Det |
| 5 | 59th | OF Jayson Werth Was |
| 6 | 62nd | 3B Martin Prado Atl |
| 7 | 83rd | RP Neftali Feliz Tex |
| 8 | 86th | OF Shane Victorino Phi |
| 9 | 107th | SS Elvis Andrus Tex |
| 10 | 110th | DH Mike Young Tex |
| 11 | 131st | C Kurt Suzuki Oak |
| 12 | 134th | SP Colby Lewis Tex |
| 13 | 155th | 1B Ike Davis NYN |
| 14 | 158th | 1B Freddie Freeman Atl |
| 15 | 179th | 3B Mike Aviles Bos |
| 16 | 182nd | RP Huston Street SD |
| 17 | 203rd | OF Brett Gardner NYA |
| 18 | 206th | SS Marcos Scutaro Bos |
| 19 | 227th | 2B Howie Kendrick LAA |
| 20 | 230th | SP Luke Hochevar KC |
| 21 | 251st | SP Barry Zito SF |
| 22 | 254th | SP Jorge de la Rosa Col |
| 23 | 275th | C Jarrod Saltalamacchia Bos |
| 24 | 278th | 3B Chone Figgins Sea |
| 25 | 299th | SP Jeff Niemann TB |
| 26 | 302nd | 2B Orlando Hudson SD |
| 27 | 323rd | DH Jim Thome Phi |
| 28 | 326th | C Jason Varitek Bos |
| 29 | 347th | SP Bartolo Colon Oak |