| Round | Overall | Player |
|---|---|---|
| 1 | 10th | OF Ryan Braun Mil |
| 2 | 15th | C Joe Mauer Min |
| 3 | 34th | SP Cliff Lee Phi |
| 4 | 39th | SP C.C. Sabathia NYA |
| 5 | 58th | SP Dan Haren LAA |
| 6 | 63rd | SP Cole Hamels Phi |
| 7 | 82nd | DH Billy Butler KC |
| 8 | 87th | OF Shane Victorino Phi |
| 9 | 106th | DH Mike Young Tex |
| 10 | 111th | RP Joe Nathan Tex |
| 11 | 130th | SS Elvis Andrus Tex |
| 12 | 135th | OF Michael Cuddyer Col |
| 13 | 154th | OF Jacoby Ellsbury Bos |
| 14 | 159th | RP Chris Perez Cle |
| 15 | 178th | SP Wandy Rodriguez Hou |
| 16 | 183rd | 3B Chone Figgins Sea |
| 17 | 202nd | OF Mike Morse Was |
| 18 | 207th | 1B Ike Davis NYN |
| 19 | 226th | 1B Freddie Freeman Atl |
| 20 | 231st | SS Miguel Tejada SF |
| 21 | 250th | SP Barry Zito SF |
| 22 | 255th | 2B Orlando Hudson SD |
| 23 | 274th | SP Johnny Cueto Cin |
| 24 | 279th | 3B Mike Moustakas KC |
| 25 | 298th | SP Tom Gorzelanny Was |
| 26 | 303rd | SP Luke Hochevar KC |
| 27 | 322nd | C Nick Hundley SD |
| 28 | 327th | OF Michael Bourn Atl |
| 29 | 346th | SP Joe Saunders Ari |