| Round | Overall | Player |
|---|---|---|
| 1 | 1st | OF Mike Trout LAA |
| 2 | 24th | SP Stephen Strasburg Was |
| 3 | 25th | SS Hanley Ramirez LAD |
| 4 | 48th | SP C.C. Sabathia NYA |
| 5 | 49th | SP Zack Greinke LAD |
| 6 | 72nd | 2B Chase Utley Phi |
| 7 | 73rd | 3B Brett Lawrie Tor |
| 8 | 96th | 1B Eric Hosmer KC |
| 9 | 97th | DH Victor Martinez Det |
| 10 | 120th | OF Nelson Cruz Tex |
| 11 | 121st | OF Desmond Jennings TB |
| 12 | 144th | RP Kenley Jansen LAD |
| 13 | 145th | SP Ian Kennedy SD |
| 14 | 168th | C Jesus Montero Sea |
| 15 | 169th | 3B Manny Machado Bal |
| 16 | 192nd | SP Josh Beckett LAD |
| 17 | 193rd | 2B Dan Uggla Atl |
| 18 | 216th | OF Starling Marte Pit |
| 19 | 217th | 1B Brandon Belt SF |
| 20 | 240th | SS Alexei Ramirez ChA |
| 21 | 241st | C Tyler Flowers ChA |
| 22 | 264th | OF Domonic Brown Phi |
| 23 | 265th | OF Colby Rasmus Tor |
| 24 | 288th | RP Ernesto Frieri LAA |
| 25 | 289th | SP Edwin Jackson ChN |
| 26 | 312th | DH Lance Berkman Tex |
| 27 | 313th | SP Michael Fiers Mil |
| 28 | 336th | SP Johan Santana NYN |
| 29 | 337th | 3B Matt Dominguez Hou |