| Round | Overall | Player |
|---|---|---|
| 1 | 12th | OF Jose Bautista Tor |
| 2 | 13th | OF Josh Hamilton LAA |
| 3 | 36th | 3B Ryan Zimmerman Was |
| 4 | 37th | 2B Ian Kinsler Det |
| 5 | 60th | 1B Paul Goldschmidt Ari |
| 6 | 61st | SP Johnny Cueto Cin |
| 7 | 84th | OF Melvin Upton Atl |
| 8 | 85th | OF Alex Gordon KC |
| 9 | 108th | RP Fernando Rodney TB |
| 10 | 109th | RP Rafael Soriano Was |
| 11 | 132nd | SP Brett Anderson Oak |
| 12 | 133rd | SP Tim Hudson Atl |
| 13 | 156th | DH David Ortiz Bos |
| 14 | 157th | SP Hiroki Kuroda NYA |
| 15 | 180th | SS J.J. Hardy Bal |
| 16 | 181st | SP Brandon McCarthy Ari |
| 17 | 204th | C Brian McCann NYA |
| 18 | 205th | SP Jaime Garcia StL |
| 19 | 228th | 2B Danny Espinosa Was |
| 20 | 229th | RP Huston Street SD |
| 21 | 252nd | 3B Lonnie Chisenhall Cle |
| 22 | 253rd | DH Adam Lind Tor |
| 23 | 276th | C Derek Norris Oak |
| 24 | 277th | SS Yunel Escobar TB |
| 25 | 300th | OF Alejandro De Aza ChA |
| 26 | 301st | SP Justin Masterson Cle |
| 27 | 324th | SP Kyle Lohse Mil |
| 28 | 325th | OF Drew Stubbs Col |
| 29 | 348th | SP Anthony Bass SD |