| Round | Overall | Player |
|---|---|---|
| 1 | 1st | OF Mike Trout LAA |
| 2 | 24th | SP Corey Kluber Cle |
| 3 | 25th | DH J.D. Martinez Bos |
| 4 | 48th | SP Justin Verlander Hou |
| 5 | 49th | 3B Rafael Devers Bos |
| 6 | 72nd | 1B Miguel Cabrera Det |
| 7 | 73rd | SS Trevor Story Col |
| 8 | 96th | SP Kyle Hendricks ChN |
| 9 | 97th | 2B D.J. LeMahieu Col |
| 10 | 120th | RP Corey Knebel Mil |
| 11 | 121st | SP Luis Castillo Cin |
| 12 | 144th | RP Felipe Vazquez Pit |
| 13 | 145th | SP Garrett Richards LAA |
| 14 | 168th | C J.T. Realmuto Mia |
| 15 | 169th | SP J.A. Happ NYA |
| 16 | 192nd | OF Scott Schebler Cin |
| 17 | 193rd | OF Trey Mancini Bal |
| 18 | 216th | SP Tanner Roark Was |
| 19 | 217th | 3B Tim Beckham Bal |
| 20 | 240th | OF Jose Pirela SD |
| 21 | 241st | SS Ketel Marte Ari |
| 22 | 264th | 1B Joe Mauer Min |
| 23 | 265th | 2B Logan Forsythe LAD |
| 24 | 288th | OF Kole Calhoun LAA |
| 25 | 289th | RP Shane Greene Det |
| 26 | 312th | C Matt Wieters Was |
| 27 | 313th | 2B Josh Harrison Pit |
| 28 | 336th | SS Bo Bichette Tor |
| 29 | 337th | OF Kevin Kiermaier TB |