| Round | Overall | Player |
|---|---|---|
| 1 | 11th | SS Francisco Lindor Cle |
| 2 | 14th | SP Chris Sale Bos |
| 3 | 35th | OF Juan Soto Was |
| 4 | 38th | SS Corey Seager LAD |
| 5 | 59th | RP Kenley Jansen LAD |
| 6 | 62nd | 3B Eugenio Suarez Cin |
| 7 | 83rd | SP Kyle Hendricks ChN |
| 8 | 86th | RP Brad Hand Cle |
| 9 | 107th | DH Edwin Encarnacion NYA |
| 10 | 110th | OF Tommy Pham SD |
| 11 | 131st | SP Joey Lucchesi SD |
| 12 | 134th | 1B Justin Smoak Tor |
| 13 | 155th | OF Aaron Hicks NYA |
| 14 | 158th | 1B Ryan McMahon Col |
| 15 | 179th | SP Marcus Stroman NYN |
| 16 | 182nd | 1B Ryan O'Hearn KC |
| 17 | 203rd | SP Aaron Sanchez Hou |
| 18 | 206th | OF Jorge Soler KC |
| 19 | 227th | SP Rich Hill LAD |
| 20 | 230th | 3B Yolmer Sanchez ChA |
| 21 | 251st | RP Shane Greene Atl |
| 22 | 254th | OF Steve Souza Ari |
| 23 | 275th | 2B Garrett Hampson Col |
| 24 | 278th | SS Andrelton Simmons LAA |
| 25 | 299th | 2B Joey Wendle TB |
| 26 | 302nd | OF Lewis Brinson Mia |
| 27 | 323rd | SP Eric Lauer Mil |
| 28 | 326th | C Tucker Barnhart Cin |
| 29 | 347th | C Omar Narváez Sea |