| Round | Overall | Player |
|---|---|---|
| 1 | 1st | OF Ronald Acuna Jr. Atl |
| 2 | 24th | SP Max Scherzer Was |
| 3 | 25th | SP Stephen Strasburg Was |
| 4 | 48th | 3B Manny Machado SD |
| 5 | 49th | OF Eloy Jimenez ChA |
| 6 | 72nd | 1B Carlos Santana KC |
| 7 | 73rd | SP Noah Syndergaard NYN |
| 8 | 96th | RP Brad Hand Cle |
| 9 | 97th | SS Marcus Semien Oak |
| 10 | 120th | OF Franmil Reyes Cle |
| 11 | 121st | SP Madison Bumgarner Ari |
| 12 | 144th | SP Zach Wheeler Phi |
| 13 | 145th | OF Willie Calhoun Tex |
| 14 | 168th | OF Hunter Dozier KC |
| 15 | 169th | 2B Robinson Cano NYN |
| 16 | 192nd | RP Brandon Workman Bos |
| 17 | 193rd | SP Dinelson Lamet SD |
| 18 | 216th | 1B Christian Walker Ari |
| 19 | 217th | C Sean Murphy Oak |
| 20 | 240th | OF Tommy Edman StL |
| 21 | 241st | 3B Kyle Seager Sea |
| 22 | 264th | C Buster Posey SF |
| 23 | 265th | SS Kevin Newman Pit |
| 24 | 288th | 2B Luis Arraez Min |
| 25 | 289th | SP Garrett Richards SD |
| 26 | 312th | OF Austin Hays Bal |
| 27 | 313th | SP Jordan Montgomery NYA |
| 28 | 336th | 1B Evan White Sea |
| 29 | 337th | SP Caleb Smith Mia |