| Round | Overall | Player |
|---|---|---|
| 1 | 5th | SS Francisco Lindor Cle |
| 2 | 20th | 3B Rafael Devers Bos |
| 3 | 29th | SP Shane Bieber Cle |
| 4 | 44th | 3B Kris Bryant ChN |
| 5 | 53rd | C J.T. Realmuto Phi |
| 6 | 68th | 1B Max Muncy LAD |
| 7 | 77th | RP Josh Hader Mil |
| 8 | 92nd | OF Nick Castellanos Cin |
| 9 | 101st | SP Brandon Woodruff Mil |
| 10 | 116th | DH Khris Davis Oak |
| 11 | 125th | 2B Brandon Lowe TB |
| 12 | 140th | SP Jake Odorizzi Min |
| 13 | 149th | OF Justin Upton LAA |
| 14 | 164th | OF Aristides Aquino Cin |
| 15 | 173rd | 3B Austin Riley Atl |
| 16 | 188th | RP Sean Doolittle Was |
| 17 | 197th | RP Alex Colome ChA |
| 18 | 212th | OF Hunter Renfroe Bos |
| 19 | 221st | SP Marco Gonzales Sea |
| 20 | 236th | 2B David Fletcher LAA |
| 21 | 245th | SP Joe Musgrove Pit |
| 22 | 260th | SS J.P. Crawford Sea |
| 23 | 269th | OF Alex Verdugo Bos |
| 24 | 284th | SS Willy Adames TB |
| 25 | 293rd | C Francisco Mejia SD |
| 26 | 308th | 1B Brandon Belt SF |
| 27 | 317th | SP Griffin Canning LAA |
| 28 | 332nd | OF Mike Yastrzemski SF |
| 29 | 341st | SP Michael Pineda Min |