| Round | Overall | Player |
|---|---|---|
| 1 | 8th | OF Juan Soto Was |
| 2 | 17th | 3B Anthony Rendon LAA |
| 3 | 32nd | SS Gleyber Torres NYA |
| 4 | 41st | DH J.D. Martinez Bos |
| 5 | 56th | 1B Rhys Hoskins Phi |
| 6 | 65th | SP Jose Berrios Min |
| 7 | 80th | OF Michael Conforto NYN |
| 8 | 89th | C Yasmani Grandal ChA |
| 9 | 104th | 2B D.J. LeMahieu NYA |
| 10 | 113th | RP Liam Hendriks Oak |
| 11 | 128th | RP Taylor Rogers Min |
| 12 | 137th | SP Eduardo Rodriguez Bos |
| 13 | 152nd | OF Kyle Schwarber ChN |
| 14 | 161st | SP Mike Minor Oak |
| 15 | 176th | SS Jorge Polanco Min |
| 16 | 185th | SP Marcus Stroman NYN |
| 17 | 200th | 1B Joey Votto Cin |
| 18 | 209th | OF Kole Calhoun Ari |
| 19 | 224th | 3B Justin Turner LAD |
| 20 | 233rd | SP Jon Lester ChN |
| 21 | 248th | RP Ian Kennedy KC |
| 22 | 257th | 2B Jurickson Profar SD |
| 23 | 272nd | SP Wade Miley Cin |
| 24 | 281st | SP Joey Lucchesi SD |
| 25 | 296th | OF Brett Gardner NYA |
| 26 | 305th | SP Rick Porcello NYN |
| 27 | 320th | OF Adam Eaton Was |
| 28 | 329th | C Martin Maldonado Hou |
| 29 | 344th | SP Homer Bailey Min |