| Round | Overall | Player |
|---|---|---|
| 1 | 11th | SP Gerrit Cole NYA |
| 2 | 14th | 3B Alex Bregman Hou |
| 3 | 35th | OF Charlie Blackmon Col |
| 4 | 38th | SP Mike Clevinger SD |
| 5 | 59th | 2B D.J. LeMahieu NYA |
| 6 | 62nd | SS Javier Baez ChN |
| 7 | 83rd | SP Pat Corbin Was |
| 8 | 86th | OF Andrew Benintendi Bos |
| 9 | 107th | RP Edwin Diaz NYN |
| 10 | 110th | DH Nelson Cruz Min |
| 11 | 131st | OF David Dahl Tex |
| 12 | 134th | 1B Yulieski Gurriel Hou |
| 13 | 155th | RP Ken Giles Tor |
| 14 | 158th | SP Lance Lynn Tex |
| 15 | 179th | RP Jose Leclerc Tex |
| 16 | 182nd | C Carson Kelly Ari |
| 17 | 203rd | 3B Jonathan Villar Tor |
| 18 | 206th | OF Shogo Akiyama Cin |
| 19 | 227th | OF J.D. Davis NYN |
| 20 | 230th | SP Ryan Yarbrough TB |
| 21 | 251st | SP Cole Hamels Atl |
| 22 | 254th | SP Alex Wood LAD |
| 23 | 275th | 1B Travis Shaw Tor |
| 24 | 278th | C Danny Jansen Tor |
| 25 | 299th | OF Brandon Nimmo NYN |
| 26 | 302nd | SP AJ Puk Oak |
| 27 | 323rd | SP Anthony DeSclafani Cin |
| 28 | 326th | SS J.P. Crawford Sea |
| 29 | 347th | 2B Nicky Lopez KC |