| Round | Overall | Player |
|---|---|---|
| 1 | 12th | SS Francisco Lindor Cle |
| 2 | 13th | 1B Peter Alonso NYN |
| 3 | 36th | OF Yordan Alvarez Hou |
| 4 | 37th | 2B Keston Hiura Mil |
| 5 | 60th | C J.T. Realmuto Phi |
| 6 | 61st | OF Austin Meadows TB |
| 7 | 84th | OF Starling Marte Ari |
| 8 | 85th | OF Michael Conforto NYN |
| 9 | 108th | 3B Eduardo Escobar Ari |
| 10 | 109th | SP Trevor Bauer Cin |
| 11 | 132nd | OF Luis Robert ChA |
| 12 | 133rd | SP Max Fried Atl |
| 13 | 156th | SP Hyun-Jin Ryu Tor |
| 14 | 157th | SP Sean Manaea Oak |
| 15 | 180th | SP Marcus Stroman NYN |
| 16 | 181st | SS Jorge Polanco Min |
| 17 | 204th | 3B Miguel Andújar NYA |
| 18 | 205th | SP Sandy Alcántra Mia |
| 19 | 228th | SP Marco Gonzales Sea |
| 20 | 229th | SP Michael Kopech ChA |
| 21 | 252nd | C Christian Vazquez Bos |
| 22 | 253rd | OF Kyle Tucker Hou |
| 23 | 276th | SP Kwang-Hyun Kim StL |
| 24 | 277th | SP MacKenzie Gore SD |
| 25 | 300th | SP Josh James Hou |
| 26 | 301st | SP Garrett Richards SD |
| 27 | 324th | 2B David Fletcher LAA |
| 28 | 325th | SP Brendan McKay TB |
| 29 | 348th | 1B Chris Davis Bal |