| Round | Overall | Player |
|---|---|---|
| 1 | 3rd | OF Ronald Acuna Jr. Atl |
| 2 | 22nd | SP Shane Bieber Cle |
| 3 | 27th | OF Aaron Judge NYA |
| 4 | 46th | SP Aaron Nola Phi |
| 5 | 51st | 3B Manny Machado SD |
| 6 | 70th | 1B Carlos Santana KC |
| 7 | 75th | SS Carlos Correa Hou |
| 8 | 94th | SP Brandon Woodruff Mil |
| 9 | 99th | RP Taylor Rogers Min |
| 10 | 118th | C Salvador Perez KC |
| 11 | 123rd | SP Corey Kluber Tex |
| 12 | 142nd | DH Khris Davis Oak |
| 13 | 147th | OF Victor Robles Was |
| 14 | 166th | RP Nick Anderson TB |
| 15 | 171st | SP Germán Márquez Col |
| 16 | 190th | 2B Jean Segura Phi |
| 17 | 195th | 1B Dan Murphy Col |
| 18 | 214th | SP Joe Musgrove Pit |
| 19 | 219th | 3B Justin Turner LAD |
| 20 | 238th | SP Nate Pearson Tor |
| 21 | 243rd | OF Lorenzo Cain Mil |
| 22 | 262nd | 2B Nick Madrigal ChA |
| 23 | 267th | C Buster Posey SF |
| 24 | 286th | SP Justus Sheffield Sea |
| 25 | 291st | SS Luis Urias Mil |
| 26 | 310th | SP Dustin May LAD |
| 27 | 315th | OF Ryan Braun Mil |
| 28 | 334th | 2B Brendan Rodgers Col |
| 29 | 339th | RP Blake Treinen LAD |