| Round | Overall | Player |
|---|---|---|
| 1 | 9th | 3B Alex Bregman Hou |
| 2 | 16th | SP Shane Bieber Cle |
| 3 | 33rd | SS Fernando Tatis Jr. SD |
| 4 | 40th | DH J.D. Martinez Bos |
| 5 | 57th | SP Jose Berrios Min |
| 6 | 64th | OF Andrew Benintendi Bos |
| 7 | 81st | SP Chris Paddack SD |
| 8 | 88th | OF Victor Robles Was |
| 9 | 105th | OF Luis Robert ChA |
| 10 | 112th | SP Julio Urías LAD |
| 11 | 129th | SS Marcus Semien Oak |
| 12 | 136th | SP Chris Sale Bos |
| 13 | 153rd | 1B Trey Mancini Bal |
| 14 | 160th | C Salvador Perez KC |
| 15 | 177th | SP Aaron Civale Cle |
| 16 | 184th | RP Joe Jimenez Det |
| 17 | 201st | OF Nick Senzel Cin |
| 18 | 208th | SP Brendan McKay TB |
| 19 | 225th | 2B Garrett Hampson Col |
| 20 | 232nd | RP Nick Anderson TB |
| 21 | 249th | C Omar Narváez Mil |
| 22 | 256th | OF Tyler O'Neill StL |
| 23 | 273rd | SP Zach Plesac Cle |
| 24 | 280th | SP Nate Pearson Tor |
| 25 | 297th | SP Pablo Lopez Mia |
| 26 | 304th | SP Tyler Mahle Cin |
| 27 | 321st | OF Ryan Braun Mil |
| 28 | 328th | SS Niko Goodrum Det |
| 29 | 345th | RP Randy Dobnak Min |