| Round | Overall | Player |
|---|---|---|
| 1 | 1st | OF Mike Trout LAA |
| 2 | 24th | DH J.D. Martinez Bos |
| 3 | 25th | OF Yordan Alvarez Hou |
| 4 | 48th | SS Gleyber Torres NYA |
| 5 | 49th | 3B Matt Chapman Oak |
| 6 | 72nd | SP Zack Greinke Hou |
| 7 | 73rd | SP Lucas Giolito ChA |
| 8 | 96th | SP Tyler Glasnow TB |
| 9 | 97th | SP Trevor Bauer Cin |
| 10 | 120th | RP Liam Hendriks Oak |
| 11 | 121st | DH Shohei Ohtani LAA |
| 12 | 144th | SP Eduardo Rodriguez Bos |
| 13 | 145th | OF Willie Calhoun Tex |
| 14 | 168th | 1B Joey Votto Cin |
| 15 | 169th | 3B Jonathan Villar Tor |
| 16 | 192nd | RP Nick Anderson TB |
| 17 | 193rd | 2B Jonathan Schoop Det |
| 18 | 216th | C Carson Kelly Ari |
| 19 | 217th | OF Andrew McCutchen Phi |
| 20 | 240th | SP Ryan Yarbrough TB |
| 21 | 241st | C Wilson Ramos NYN |
| 22 | 264th | 3B Carter Kieboom Was |
| 23 | 265th | RP Joe Jimenez Det |
| 24 | 288th | SP Garrett Richards SD |
| 25 | 289th | SP Jose Quintana ChN |
| 26 | 312th | SS Niko Goodrum Det |
| 27 | 313th | 2B David Fletcher LAA |
| 28 | 336th | 1B Howie Kendrick Was |
| 29 | 337th | OF Brandon Nimmo NYN |