| Round | Overall | Player |
|---|---|---|
| 1 | 3rd | OF Christian Yelich Mil |
| 2 | 22nd | SS Fernando Tatis Jr. SD |
| 3 | 27th | 2B Ozzie Albies Atl |
| 4 | 46th | 3B Eugenio Suarez Cin |
| 5 | 51st | SP Stephen Strasburg Was |
| 6 | 70th | OF Marcell Ozuna Atl |
| 7 | 75th | SP Jose Berrios Min |
| 8 | 94th | SP Zach Wheeler Phi |
| 9 | 99th | C Mitch Garver Min |
| 10 | 118th | 1B Luke Voit NYA |
| 11 | 123rd | OF Mark Canha Oak |
| 12 | 142nd | SP James Paxton NYA |
| 13 | 147th | SP Dallas Keuchel ChA |
| 14 | 166th | 2B Rougned Odor Tex |
| 15 | 171st | 1B Christian Walker Ari |
| 16 | 190th | SP Germán Márquez Col |
| 17 | 195th | OF Hunter Renfroe Bos |
| 18 | 214th | SP Johnny Cueto SF |
| 19 | 219th | 3B Miguel Andújar NYA |
| 20 | 238th | SP Nathan Eovaldi Bos |
| 21 | 243rd | OF Danny Santana Tex |
| 22 | 262nd | C Omar Narváez Mil |
| 23 | 267th | SS Andrelton Simmons LAA |
| 24 | 286th | SP Zach Plesac Cle |
| 25 | 291st | OF Mike Yastrzemski SF |
| 26 | 310th | DH Renato Núñez Bal |
| 27 | 315th | SP Collin McHugh Bos |
| 28 | 334th | SP Jeff Samardzija SF |
| 29 | 339th | SP Kyle Wright Atl |