| Round | Overall | Player |
|---|---|---|
| 1 | 5th | 2B Jose Altuve Hou |
| 2 | 20th | SS Fernando Tatis Jr. SD |
| 3 | 29th | OF Mike Trout LAA |
| 4 | 44th | DH J.D. Martinez Bos |
| 5 | 53rd | SP Jack Flaherty StL |
| 6 | 68th | SP Aaron Nola Phi |
| 7 | 77th | 1B Jose Abreu ChA |
| 8 | 92nd | SP Chris Paddack SD |
| 9 | 101st | RP Brad Hand Cle |
| 10 | 116th | SP Brandon Woodruff Mil |
| 11 | 125th | OF Whit Merrifield KC |
| 12 | 140th | OF Victor Robles Was |
| 13 | 149th | SP Yu Darvish ChN |
| 14 | 164th | SP Michael Fiers Oak |
| 15 | 173rd | 3B Jonathan Villar Tor |
| 16 | 188th | C Salvador Perez KC |
| 17 | 197th | 3B Justin Turner LAD |
| 18 | 212th | 1B Dan Vogelbach Sea |
| 19 | 221st | OF Alex Verdugo Bos |
| 20 | 236th | RP Sean Doolittle Was |
| 21 | 245th | C Omar Narváez Mil |
| 22 | 260th | SP Andrew Heaney LAA |
| 23 | 269th | 2B Robinson Cano NYN |
| 24 | 284th | SP Kenta Maeda Min |
| 25 | 293rd | SS Willy Adames TB |
| 26 | 308th | OF Brett Gardner NYA |
| 27 | 317th | SP Nathan Eovaldi Bos |
| 28 | 332nd | 1B Jesus Aguilar Mia |
| 29 | 341st | RP Fernando Abad SF |