| Round | Overall | Player |
|---|---|---|
| 1 | 11th | 1B Paul Goldschmidt StL |
| 2 | 14th | 1B Miguel Sano Min |
| 3 | 35th | OF Cody Bellinger LAD |
| 4 | 38th | OF Juan Soto Was |
| 5 | 59th | SP Clayton Kershaw LAD |
| 6 | 62nd | SP Max Scherzer Was |
| 7 | 83rd | 2B Cavan Biggio Tor |
| 8 | 86th | 3B Eduardo Escobar Ari |
| 9 | 107th | SP Frankie Montas Oak |
| 10 | 110th | DH Shohei Ohtani LAA |
| 11 | 131st | SP Corey Kluber Tex |
| 12 | 134th | 1B Luke Voit NYA |
| 13 | 155th | SS Adalberto Mondesà KC |
| 14 | 158th | OF Justin Upton LAA |
| 15 | 179th | OF Sam Hilliard Col |
| 16 | 182nd | SP Nate Pearson Tor |
| 17 | 203rd | C Tom Murphy Sea |
| 18 | 206th | SP Spencer Howard Phi |
| 19 | 227th | 3B Nick Solak Tex |
| 20 | 230th | OF Mark Canha Oak |
| 21 | 251st | OF Dylan Carlson StL |
| 22 | 254th | RP Ken Giles Tor |
| 23 | 275th | RP Hunter Harvey Bal |
| 24 | 278th | SP Mitch Keller Pit |
| 25 | 299th | OF Tommy Edman StL |
| 26 | 302nd | C Danny Jansen Tor |
| 27 | 323rd | SS Luis Urias Mil |
| 28 | 326th | 2B Jurickson Profar SD |
| 29 | 347th | C Yadier Molina StL |