| Round | Overall | Player |
|---|---|---|
| 1 | 9th | C J.T. Realmuto Phi |
| 2 | 16th | 3B Yoan Moncada ChA |
| 3 | 33rd | 3B Eugenio Suarez Cin |
| 4 | 40th | OF Mookie Betts LAD |
| 5 | 57th | SP Shane Bieber Cle |
| 6 | 64th | RP Liam Hendriks Oak |
| 7 | 81st | OF Michael Conforto NYN |
| 8 | 88th | SS Corey Seager LAD |
| 9 | 105th | 2B Mike Moustakas Cin |
| 10 | 112th | SP Kyle Hendricks ChN |
| 11 | 129th | OF Michael Brantley KC |
| 12 | 136th | OF Kyle Schwarber ChN |
| 13 | 153rd | 1B Yulieski Gurriel Hou |
| 14 | 160th | RP Carlos Martinez StL |
| 15 | 177th | 2B Ryan McMahon Col |
| 16 | 184th | SP Germán Márquez Col |
| 17 | 201st | RP Alex Colome ChA |
| 18 | 208th | SS Amed Rosario NYN |
| 19 | 225th | RP Nick Anderson TB |
| 20 | 232nd | SP Joe Musgrove Pit |
| 21 | 249th | SS Elvis Andrus Tex |
| 22 | 256th | SP Jose Quintana ChN |
| 23 | 273rd | SP Steven Matz NYN |
| 24 | 280th | DH Renato Núñez Bal |
| 25 | 297th | SP Jeff Samardzija SF |
| 26 | 304th | 3B Johan Camargo Atl |
| 27 | 321st | OF Corey Dickerson Mia |
| 28 | 328th | 1B Mitch Moreland SD |
| 29 | 345th | C Victor Caratini ChN |