| Round | Overall | Player |
|---|---|---|
| 1 | 10th | SS Francisco Lindor Cle |
| 2 | 15th | 3B Nolan Arenado Col |
| 3 | 34th | OF Austin Meadows TB |
| 4 | 39th | SP Jack Flaherty StL |
| 5 | 58th | 1B Anthony Rizzo ChN |
| 6 | 63rd | SP Mike Clevinger SD |
| 7 | 82nd | OF Victor Robles Was |
| 8 | 87th | 2B Gavin Lux LAD |
| 9 | 106th | OF Nick Castellanos Cin |
| 10 | 111th | RP Liam Hendriks Oak |
| 11 | 130th | OF Andrew Benintendi Bos |
| 12 | 135th | SP Julio Urías LAD |
| 13 | 154th | 1B Luke Voit NYA |
| 14 | 159th | SP Max Fried Atl |
| 15 | 178th | RP Hector Neris Phi |
| 16 | 183rd | OF Dylan Carlson StL |
| 17 | 202nd | 3B Scott Kingery Phi |
| 18 | 207th | 3B Miguel Andújar NYA |
| 19 | 226th | C Wilson Ramos NYN |
| 20 | 231st | SS Kevin Newman Pit |
| 21 | 250th | SP Andrew Heaney LAA |
| 22 | 255th | RP Brandon Workman Bos |
| 23 | 274th | SP Spencer Howard Phi |
| 24 | 279th | OF Sam Hilliard Col |
| 25 | 298th | SP Rick Porcello NYN |
| 26 | 303rd | SP Josh James Hou |
| 27 | 322nd | SP J.A. Happ NYA |
| 28 | 327th | 2B Cesar Hernández Cle |
| 29 | 346th | SP Casey Mize Det |