| Round | Overall | Player |
|---|---|---|
| 1 | 8th | OF Bryce Harper Phi |
| 2 | 17th | SP Gerrit Cole NYA |
| 3 | 32nd | OF Eloy Jimenez ChA |
| 4 | 41st | 3B Manny Machado SD |
| 5 | 56th | OF Charlie Blackmon Col |
| 6 | 65th | OF Luis Robert ChA |
| 7 | 80th | C J.T. Realmuto Phi |
| 8 | 89th | SS Jorge Polanco Min |
| 9 | 104th | 1B Carlos Santana KC |
| 10 | 113th | SP Yu Darvish ChN |
| 11 | 128th | 2B Brandon Lowe TB |
| 12 | 137th | 2B Nico Hoerner ChN |
| 13 | 152nd | OF Kyle Tucker Hou |
| 14 | 161st | DH Edwin Encarnacion ChA |
| 15 | 176th | RP Craig Kimbrel ChN |
| 16 | 185th | SP Germán Márquez Col |
| 17 | 200th | RP Archie Bradley Ari |
| 18 | 209th | SP David Price LAD |
| 19 | 224th | RP Jose Leclerc Tex |
| 20 | 233rd | SP Nate Pearson Tor |
| 21 | 248th | SP Jonathan Gray Col |
| 22 | 257th | 1B Joey Votto Cin |
| 23 | 272nd | SP Jon Lester ChN |
| 24 | 281st | 3B Ryan Mountcastle Bal |
| 25 | 296th | 2B Nick Madrigal ChA |
| 26 | 305th | SP Yusei Kikuchi Sea |
| 27 | 320th | RP Kevin Ginkel Ari |
| 28 | 329th | SS Luis Urias Mil |
| 29 | 344th | SP Rafael Montero Tex |