| Round | Overall | Player |
|---|---|---|
| 1 | 7th | OF Mookie Betts LAD |
| 2 | 18th | 3B Anthony Rendon LAA |
| 3 | 31st | SP Mike Soroka Atl |
| 4 | 42nd | SS Bo Bichette Tor |
| 5 | 55th | RP Roberto Osuna Hou |
| 6 | 66th | 1B Miguel Sano Min |
| 7 | 79th | SP Eduardo Rodriguez Bos |
| 8 | 90th | OF Max Kepler Min |
| 9 | 103rd | SP Lance McCullers Hou |
| 10 | 114th | 2B Ryan McMahon Col |
| 11 | 127th | SS Jorge Polanco Min |
| 12 | 138th | RP Brad Hand Cle |
| 13 | 151st | OF Domingo Santana Cle |
| 14 | 162nd | SP Aaron Civale Cle |
| 15 | 175th | SS Tim Anderson ChA |
| 16 | 186th | SP Johnny Cueto SF |
| 17 | 199th | C Christian Vazquez Bos |
| 18 | 210th | 3B Kyle Seager Sea |
| 19 | 223rd | SP Jon Lester ChN |
| 20 | 234th | 1B Dan Vogelbach Sea |
| 21 | 247th | OF Alex Verdugo Bos |
| 22 | 258th | 2B Jurickson Profar SD |
| 23 | 271st | SP Steven Matz NYN |
| 24 | 282nd | C Robinson Chirinos Tex |
| 25 | 295th | SP Yonny Chirinos TB |
| 26 | 306th | OF Brett Gardner NYA |
| 27 | 319th | SP Zach Plesac Cle |
| 28 | 330th | OF Yasiel Puig Atl |
| 29 | 343rd | SP Felix Hernandez Atl |