| Round | Overall | Player |
|---|---|---|
| 1 | 10th | SP Gerrit Cole NYA |
| 2 | 15th | OF Bryce Harper Phi |
| 3 | 34th | SS Fernando Tatis Jr. SD |
| 4 | 39th | 1B Anthony Rizzo ChN |
| 5 | 58th | 3B Kris Bryant ChN |
| 6 | 63rd | OF Jorge Soler KC |
| 7 | 82nd | RP Liam Hendriks Oak |
| 8 | 87th | SP Mike Minor Oak |
| 9 | 106th | 2B Cavan Biggio Tor |
| 10 | 111th | C Will Smith LAD |
| 11 | 130th | RP Taylor Rogers Min |
| 12 | 135th | OF Lourdes Gurriel Tor |
| 13 | 154th | SP Dakota Hudson StL |
| 14 | 159th | RP Raisel Iglesias LAA |
| 15 | 178th | SP Jose Urquidy Hou |
| 16 | 183rd | SS Paul DeJong StL |
| 17 | 202nd | 3B Jonathan Villar Tor |
| 18 | 207th | 2B Brandon Lowe TB |
| 19 | 226th | OF Kole Calhoun Ari |
| 20 | 231st | OF Nomar Mazara ChA |
| 21 | 250th | SP Miles Mikolas StL |
| 22 | 255th | OF Byron Buxton Min |
| 23 | 274th | SP Wade Miley Cin |
| 24 | 279th | DH Shin-Soo Choo Tex |
| 25 | 298th | 1B Brandon Belt SF |
| 26 | 303rd | C Yadier Molina StL |
| 27 | 322nd | RP Wade Davis Col |
| 28 | 327th | SP Merrill Kelly Ari |
| 29 | 346th | SP Jordan Montgomery NYA |